Notch-Mediated Cell Adhesion
Notch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; however, information on the physiological roles of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-01-01
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| Series: | Biology |
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| Online Access: | http://www.mdpi.com/2079-7737/5/1/5 |
| _version_ | 1797762524732456960 |
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| author | Akihiko Murata Shin-Ichi Hayashi |
| author_facet | Akihiko Murata Shin-Ichi Hayashi |
| author_sort | Akihiko Murata |
| collection | DOAJ |
| description | Notch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; however, information on the physiological roles of this function and its origin is limited. In this review, we discuss the potential present and ancestral roles of Notch-mediated cell adhesion in order to explore its origin and the initial roles of Notch family members dating back to metazoan evolution. We hypothesize that Notch family members may have initially emerged as cell adhesion molecules in order to mediate multicellularity in the last common ancestor of metazoan organisms. |
| first_indexed | 2024-03-12T19:28:37Z |
| format | Article |
| id | doaj.art-723e4ef3b32a45bc863ace74a61d8ee2 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T19:28:37Z |
| publishDate | 2016-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-723e4ef3b32a45bc863ace74a61d8ee22023-08-02T04:43:22ZengMDPI AGBiology2079-77372016-01-0151510.3390/biology5010005biology5010005Notch-Mediated Cell AdhesionAkihiko Murata0Shin-Ichi Hayashi1Department of Molecular and Cellular Biology, Division of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, JapanDepartment of Molecular and Cellular Biology, Division of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, JapanNotch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; however, information on the physiological roles of this function and its origin is limited. In this review, we discuss the potential present and ancestral roles of Notch-mediated cell adhesion in order to explore its origin and the initial roles of Notch family members dating back to metazoan evolution. We hypothesize that Notch family members may have initially emerged as cell adhesion molecules in order to mediate multicellularity in the last common ancestor of metazoan organisms.http://www.mdpi.com/2079-7737/5/1/5NotchDelta/Delta-likeSerrate/Jaggedcell adhesionmetazoan evolution |
| spellingShingle | Akihiko Murata Shin-Ichi Hayashi Notch-Mediated Cell Adhesion Biology Notch Delta/Delta-like Serrate/Jagged cell adhesion metazoan evolution |
| title | Notch-Mediated Cell Adhesion |
| title_full | Notch-Mediated Cell Adhesion |
| title_fullStr | Notch-Mediated Cell Adhesion |
| title_full_unstemmed | Notch-Mediated Cell Adhesion |
| title_short | Notch-Mediated Cell Adhesion |
| title_sort | notch mediated cell adhesion |
| topic | Notch Delta/Delta-like Serrate/Jagged cell adhesion metazoan evolution |
| url | http://www.mdpi.com/2079-7737/5/1/5 |
| work_keys_str_mv | AT akihikomurata notchmediatedcelladhesion AT shinichihayashi notchmediatedcelladhesion |