Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of <i>Lycium chinense</i> Miller
This study aimed at investigating the <i>Lycium chinense</i> Miller leaf extract mineral and phenolic compound profiles as well as antioxidant and antimicrobial potential. We determined the leaf extract mineral composition, identified its major mineral components, and quantified secondar...
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MDPI AG
2020-08-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/9/8/1023 |
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| author | Muthu Thiruvengadam Bimal Kumar Ghimire Seung-Hyun Kim Chang Yeon Yu Deog-Hwan Oh Ramachandran Chelliah Chang Kwon Yun-Ju Kim Ill Min Chung |
| author_facet | Muthu Thiruvengadam Bimal Kumar Ghimire Seung-Hyun Kim Chang Yeon Yu Deog-Hwan Oh Ramachandran Chelliah Chang Kwon Yun-Ju Kim Ill Min Chung |
| author_sort | Muthu Thiruvengadam |
| collection | DOAJ |
| description | This study aimed at investigating the <i>Lycium chinense</i> Miller leaf extract mineral and phenolic compound profiles as well as antioxidant and antimicrobial potential. We determined the leaf extract mineral composition, identified its major mineral components, and quantified secondary metabolites. We also measured the leaf extract antioxidant potential and found that it varies in a concentration-dependent manner. We observed a significant and higher positive correlation between DPPH and ABTS assays compared with the total phenolic and flavonoid content. Furthermore, our assay results positively correlated with several observed acids, indicating their strong association with the <i>L. chinense</i> antioxidant potential. Our cytotoxic assay revealed weak toxicity at higher tested concentrations. Our MIC assay showed that the 80% methanol extract effectively inhibited the growth of <i>Escherichia coli</i> Castellani and Chalmers (ATCC35150). The 625-ppm leaf extract completely suppressed the growth of <i>Staphylococcus aureus</i> Rosenbach (ATCC13150), <i>Bacillus cereus</i> (ATCC 14579), and <i>Helicobacter pylori</i> (ATCC43504). These results allow us to understand the indigenous medicinal value of <i>L. chinense</i>. Our study suggests that the <i>L. chinense</i> leaf extract phenolic compounds possess a good antioxidant activity against free radicals and are effective antimicrobial agents. Finally, the presence and high level of diverse minerals suggest the potential of <i>L. chinense</i> for nutraceutical and functional food applications. |
| first_indexed | 2024-03-10T17:30:41Z |
| format | Article |
| id | doaj.art-723f2c2fa25c4564af9067fce3d27ad4 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T17:30:41Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-723f2c2fa25c4564af9067fce3d27ad42023-11-20T10:01:22ZengMDPI AGPlants2223-77472020-08-0198102310.3390/plants9081023Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of <i>Lycium chinense</i> MillerMuthu Thiruvengadam0Bimal Kumar Ghimire1Seung-Hyun Kim2Chang Yeon Yu3Deog-Hwan Oh4Ramachandran Chelliah5Chang Kwon6Yun-Ju Kim7Ill Min Chung8Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, KoreaDepartment of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, KoreaDepartment of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, KoreaBioherb Research Institute, Kangwon National University, Chuncheon 24341, KoreaFood Science and Biotechnology, Kangwon National University, Chuncheon 24341, KoreaFood Science and Biotechnology, Kangwon National University, Chuncheon 24341, KoreaDepartment of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, KoreaDepartment of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, KoreaDepartment of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, KoreaThis study aimed at investigating the <i>Lycium chinense</i> Miller leaf extract mineral and phenolic compound profiles as well as antioxidant and antimicrobial potential. We determined the leaf extract mineral composition, identified its major mineral components, and quantified secondary metabolites. We also measured the leaf extract antioxidant potential and found that it varies in a concentration-dependent manner. We observed a significant and higher positive correlation between DPPH and ABTS assays compared with the total phenolic and flavonoid content. Furthermore, our assay results positively correlated with several observed acids, indicating their strong association with the <i>L. chinense</i> antioxidant potential. Our cytotoxic assay revealed weak toxicity at higher tested concentrations. Our MIC assay showed that the 80% methanol extract effectively inhibited the growth of <i>Escherichia coli</i> Castellani and Chalmers (ATCC35150). The 625-ppm leaf extract completely suppressed the growth of <i>Staphylococcus aureus</i> Rosenbach (ATCC13150), <i>Bacillus cereus</i> (ATCC 14579), and <i>Helicobacter pylori</i> (ATCC43504). These results allow us to understand the indigenous medicinal value of <i>L. chinense</i>. Our study suggests that the <i>L. chinense</i> leaf extract phenolic compounds possess a good antioxidant activity against free radicals and are effective antimicrobial agents. Finally, the presence and high level of diverse minerals suggest the potential of <i>L. chinense</i> for nutraceutical and functional food applications.https://www.mdpi.com/2223-7747/9/8/1023<i>Lycium chinense</i>MTT assayMIC assaymicroorganismssecondary metabolitesleaf extract |
| spellingShingle | Muthu Thiruvengadam Bimal Kumar Ghimire Seung-Hyun Kim Chang Yeon Yu Deog-Hwan Oh Ramachandran Chelliah Chang Kwon Yun-Ju Kim Ill Min Chung Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of <i>Lycium chinense</i> Miller Plants <i>Lycium chinense</i> MTT assay MIC assay microorganisms secondary metabolites leaf extract |
| title | Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of <i>Lycium chinense</i> Miller |
| title_full | Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of <i>Lycium chinense</i> Miller |
| title_fullStr | Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of <i>Lycium chinense</i> Miller |
| title_full_unstemmed | Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of <i>Lycium chinense</i> Miller |
| title_short | Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of <i>Lycium chinense</i> Miller |
| title_sort | assessment of mineral and phenolic profiles and their association with the antioxidant cytotoxic effect and antimicrobial potential of i lycium chinense i miller |
| topic | <i>Lycium chinense</i> MTT assay MIC assay microorganisms secondary metabolites leaf extract |
| url | https://www.mdpi.com/2223-7747/9/8/1023 |
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