The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10479-4 |
| _version_ | 1818753848932564992 |
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| author | Pei Zhu Chunping Zhang Yongxing Gao Furen Wu Yalu Zhou Wen-Shu Wu |
| author_facet | Pei Zhu Chunping Zhang Yongxing Gao Furen Wu Yalu Zhou Wen-Shu Wu |
| author_sort | Pei Zhu |
| collection | DOAJ |
| description | Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defects. |
| first_indexed | 2024-12-18T05:13:53Z |
| format | Article |
| id | doaj.art-723f96fddfe440c2b28aee7a57cb3f10 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:13:53Z |
| publishDate | 2019-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-723f96fddfe440c2b28aee7a57cb3f102022-12-21T21:19:48ZengNature PortfolioNature Communications2041-17232019-06-0110111610.1038/s41467-019-10479-4The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell agingPei Zhu0Chunping Zhang1Yongxing Gao2Furen Wu3Yalu Zhou4Wen-Shu Wu5Department of Medicine, College of Medicine, University of Illinois at ChicagoDepartment of Medicine, College of Medicine, University of Illinois at ChicagoDepartment of Medicine, The Johns Hopkins University School of MedicineDepartment of Medicine, College of Medicine, University of Illinois at ChicagoDepartment of Medicine, College of Medicine, University of Illinois at ChicagoDepartment of Medicine, College of Medicine, University of Illinois at ChicagoMuscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defects.https://doi.org/10.1038/s41467-019-10479-4 |
| spellingShingle | Pei Zhu Chunping Zhang Yongxing Gao Furen Wu Yalu Zhou Wen-Shu Wu The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging Nature Communications |
| title | The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging |
| title_full | The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging |
| title_fullStr | The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging |
| title_full_unstemmed | The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging |
| title_short | The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging |
| title_sort | transcription factor slug represses p16ink4a and regulates murine muscle stem cell aging |
| url | https://doi.org/10.1038/s41467-019-10479-4 |
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