Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-12-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8247/5/1/61/ |
| _version_ | 1818400752316448768 |
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| author | Taishi Higashi Hidetoshi Arima Keiichi Motoyama |
| author_facet | Taishi Higashi Hidetoshi Arima Keiichi Motoyama |
| author_sort | Taishi Higashi |
| collection | DOAJ |
| description | Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system. |
| first_indexed | 2024-12-14T07:41:34Z |
| format | Article |
| id | doaj.art-72405aba17334e8a8b40ab9d7e940f8a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-14T07:41:34Z |
| publishDate | 2011-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-72405aba17334e8a8b40ab9d7e940f8a2022-12-21T23:11:01ZengMDPI AGPharmaceuticals1424-82472011-12-0151617810.3390/ph5010061Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNATaishi HigashiHidetoshi ArimaKeiichi MotoyamaCyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system.http://www.mdpi.com/1424-8247/5/1/61/cyclodextrinpolyamidoamine dendrimerconjugatesiRNA deliverymultifunction |
| spellingShingle | Taishi Higashi Hidetoshi Arima Keiichi Motoyama Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA Pharmaceuticals cyclodextrin polyamidoamine dendrimer conjugate siRNA delivery multifunction |
| title | Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA |
| title_full | Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA |
| title_fullStr | Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA |
| title_full_unstemmed | Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA |
| title_short | Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA |
| title_sort | potential use of polyamidoamine dendrimer conjugates with cyclodextrins as novel carriers for sirna |
| topic | cyclodextrin polyamidoamine dendrimer conjugate siRNA delivery multifunction |
| url | http://www.mdpi.com/1424-8247/5/1/61/ |
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