Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phas...

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Bibliographic Details
Main Authors: Taishi Higashi, Hidetoshi Arima, Keiichi Motoyama
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Pharmaceuticals
Subjects:
cyclodextrin
polyamidoamine dendrimer
conjugate
siRNA delivery
multifunction
Online Access:http://www.mdpi.com/1424-8247/5/1/61/

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