Epigenetic Regulations of AhR in the Aspect of Immunomodulation
Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and many other physiological processes such as adapti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6404 |
| _version_ | 1797554709497643008 |
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| author | Anna Wajda Joanna Łapczuk-Romańska Agnieszka Paradowska-Gorycka |
| author_facet | Anna Wajda Joanna Łapczuk-Romańska Agnieszka Paradowska-Gorycka |
| author_sort | Anna Wajda |
| collection | DOAJ |
| description | Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and many other physiological processes such as adaptive metabolism. In recent years, epigenetic mechanisms have provided new insight into gene regulation and reveal a new contribution to autoimmune disease pathogenesis. DNA methylation, histone modifications, chromatin alterations, microRNA and consequently non-genetic changes in phenotypes connect with environmental factors. Increasing data reveals AhR cross-roads with the most significant in immunology pathways. Although study on epigenetic modulations in autoimmune diseases is still not well understood, therefore future research will help us understand their pathophysiology and help to find new therapeutic strategies. Present literature review sheds the light on the common ground between remodeling chromatin compounds and autoimmune antibodies used in diagnostics. In the proposed review we summarize recent findings that describe epigenetic factors which regulate AhR activity and impact diverse immunological responses and pathological changes. |
| first_indexed | 2024-03-10T16:36:50Z |
| format | Article |
| id | doaj.art-72412ab92b744b94ab529f736e1c98f7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:36:50Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-72412ab92b744b94ab529f736e1c98f72023-11-20T12:24:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012117640410.3390/ijms21176404Epigenetic Regulations of AhR in the Aspect of ImmunomodulationAnna Wajda0Joanna Łapczuk-Romańska1Agnieszka Paradowska-Gorycka2Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, PolandDepartment of Experimental and Clinical Pharmacology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, PolandEnvironmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and many other physiological processes such as adaptive metabolism. In recent years, epigenetic mechanisms have provided new insight into gene regulation and reveal a new contribution to autoimmune disease pathogenesis. DNA methylation, histone modifications, chromatin alterations, microRNA and consequently non-genetic changes in phenotypes connect with environmental factors. Increasing data reveals AhR cross-roads with the most significant in immunology pathways. Although study on epigenetic modulations in autoimmune diseases is still not well understood, therefore future research will help us understand their pathophysiology and help to find new therapeutic strategies. Present literature review sheds the light on the common ground between remodeling chromatin compounds and autoimmune antibodies used in diagnostics. In the proposed review we summarize recent findings that describe epigenetic factors which regulate AhR activity and impact diverse immunological responses and pathological changes.https://www.mdpi.com/1422-0067/21/17/6404AhRepigeneticimmunomodulationautoimmunity |
| spellingShingle | Anna Wajda Joanna Łapczuk-Romańska Agnieszka Paradowska-Gorycka Epigenetic Regulations of AhR in the Aspect of Immunomodulation International Journal of Molecular Sciences AhR epigenetic immunomodulation autoimmunity |
| title | Epigenetic Regulations of AhR in the Aspect of Immunomodulation |
| title_full | Epigenetic Regulations of AhR in the Aspect of Immunomodulation |
| title_fullStr | Epigenetic Regulations of AhR in the Aspect of Immunomodulation |
| title_full_unstemmed | Epigenetic Regulations of AhR in the Aspect of Immunomodulation |
| title_short | Epigenetic Regulations of AhR in the Aspect of Immunomodulation |
| title_sort | epigenetic regulations of ahr in the aspect of immunomodulation |
| topic | AhR epigenetic immunomodulation autoimmunity |
| url | https://www.mdpi.com/1422-0067/21/17/6404 |
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