The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern Taiwan
Background: Glomerular disease is one of the leading causes of chronic kidney disease in children worldwide. Recent studies outlined the changing spectrum of glomerular disease in certain countries. Therefore, our study aimed to evaluate the histopathological patterns and changes in pediatric kidney...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957222001784 |
| _version_ | 1811177281556578304 |
|---|---|
| author | Chen-Wei Yen Tai-Di Chen Tzung-Hai Yen Mei-Ching Yu |
| author_facet | Chen-Wei Yen Tai-Di Chen Tzung-Hai Yen Mei-Ching Yu |
| author_sort | Chen-Wei Yen |
| collection | DOAJ |
| description | Background: Glomerular disease is one of the leading causes of chronic kidney disease in children worldwide. Recent studies outlined the changing spectrum of glomerular disease in certain countries. Therefore, our study aimed to evaluate the histopathological patterns and changes in pediatric kidney disease over the past 18 years in northern Taiwan. Methods: This was a retrospective chart review study of pediatric patients (≤18 years of age) undergoing percutaneous renal biopsies (PRBs) of native kidneys between January 2002 and July 2020 from a Pediatric Care Center at Chang Gung Memorial Hospital, Taoyuan, Taiwan. Results: This study analyzed a total of 339 pediatric native PRBs. The mean age of the subjects was 13.7 ± 7.0 years (184 girls and 155 boys). The most common indications of PRBs included acute nephritic syndrome (55.7%), idiopathic nephrotic syndrome (22.7%), persistent asymptomatic hematuria (13.9%), and unexplained renal failure (7.7%). Our study revealed that proliferative lupus nephritis (LN), minimal change disease (MCD)-related nephrotic syndrome, and IgA nephropathy (IgAN) were the most frequent biopsy-proven pediatric glomerular diseases. In addition, we showed that severe acute post-streptococcal glomerulonephritis (APSGN) was infrequent and has not even been diagnosed since 2010. Conclusion: Our result revealed that the spectrum of biopsy-proven pediatric kidney disease has not changed significantly over the past two decades. Furthermore, proliferative LN, MCD, and primary IgAN continue to be the most common histopathological diagnoses among Taiwanese children. |
| first_indexed | 2024-04-10T22:59:04Z |
| format | Article |
| id | doaj.art-72424c7c21f342d2af9e78c8ae8da725 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-04-10T22:59:04Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-72424c7c21f342d2af9e78c8ae8da7252023-01-14T04:26:26ZengElsevierPediatrics and Neonatology1875-95722023-01-016412631The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern TaiwanChen-Wei Yen0Tai-Di Chen1Tzung-Hai Yen2Mei-Ching Yu3Department of Pediatric Nephrology, Lin-Kou Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Anatomic Pathology, Lin-Kou Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Nephrology and Clinical Poison and Kidney Research Center, Lin-Kou Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Pediatric Nephrology, Lin-Kou Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. PhD, Department of Pediatric Nephrology, Lin-Kou Chang Gung Memorial Hospital, 5 Fusing Street, Gueishan, Taoyuan 333, Taiwan.Background: Glomerular disease is one of the leading causes of chronic kidney disease in children worldwide. Recent studies outlined the changing spectrum of glomerular disease in certain countries. Therefore, our study aimed to evaluate the histopathological patterns and changes in pediatric kidney disease over the past 18 years in northern Taiwan. Methods: This was a retrospective chart review study of pediatric patients (≤18 years of age) undergoing percutaneous renal biopsies (PRBs) of native kidneys between January 2002 and July 2020 from a Pediatric Care Center at Chang Gung Memorial Hospital, Taoyuan, Taiwan. Results: This study analyzed a total of 339 pediatric native PRBs. The mean age of the subjects was 13.7 ± 7.0 years (184 girls and 155 boys). The most common indications of PRBs included acute nephritic syndrome (55.7%), idiopathic nephrotic syndrome (22.7%), persistent asymptomatic hematuria (13.9%), and unexplained renal failure (7.7%). Our study revealed that proliferative lupus nephritis (LN), minimal change disease (MCD)-related nephrotic syndrome, and IgA nephropathy (IgAN) were the most frequent biopsy-proven pediatric glomerular diseases. In addition, we showed that severe acute post-streptococcal glomerulonephritis (APSGN) was infrequent and has not even been diagnosed since 2010. Conclusion: Our result revealed that the spectrum of biopsy-proven pediatric kidney disease has not changed significantly over the past two decades. Furthermore, proliferative LN, MCD, and primary IgAN continue to be the most common histopathological diagnoses among Taiwanese children.http://www.sciencedirect.com/science/article/pii/S1875957222001784IgA nephropathyLupus nephritisMinimal change disease |
| spellingShingle | Chen-Wei Yen Tai-Di Chen Tzung-Hai Yen Mei-Ching Yu The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern Taiwan Pediatrics and Neonatology IgA nephropathy Lupus nephritis Minimal change disease |
| title | The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern Taiwan |
| title_full | The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern Taiwan |
| title_fullStr | The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern Taiwan |
| title_full_unstemmed | The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern Taiwan |
| title_short | The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern Taiwan |
| title_sort | pathological spectrum of pediatric kidney disease 18 year experience from a single tertiary care center in northern taiwan |
| topic | IgA nephropathy Lupus nephritis Minimal change disease |
| url | http://www.sciencedirect.com/science/article/pii/S1875957222001784 |
| work_keys_str_mv | AT chenweiyen thepathologicalspectrumofpediatrickidneydisease18yearexperiencefromasingletertiarycarecenterinnortherntaiwan AT taidichen thepathologicalspectrumofpediatrickidneydisease18yearexperiencefromasingletertiarycarecenterinnortherntaiwan AT tzunghaiyen thepathologicalspectrumofpediatrickidneydisease18yearexperiencefromasingletertiarycarecenterinnortherntaiwan AT meichingyu thepathologicalspectrumofpediatrickidneydisease18yearexperiencefromasingletertiarycarecenterinnortherntaiwan AT chenweiyen pathologicalspectrumofpediatrickidneydisease18yearexperiencefromasingletertiarycarecenterinnortherntaiwan AT taidichen pathologicalspectrumofpediatrickidneydisease18yearexperiencefromasingletertiarycarecenterinnortherntaiwan AT tzunghaiyen pathologicalspectrumofpediatrickidneydisease18yearexperiencefromasingletertiarycarecenterinnortherntaiwan AT meichingyu pathologicalspectrumofpediatrickidneydisease18yearexperiencefromasingletertiarycarecenterinnortherntaiwan |