Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru
<b>Background</b>. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to asses...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/3/260 |
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| author | José-Manuel Ramos-Rincón Sonia Ortiz-Martínez María-Esteyner Vásquez-Chasnamote Eva de-Miguel-Balsa Olga-Nohelia Gamboa-Paredes Michael-John Talledo-Albujar Giovanni López-Campana Juan Carlos Celis-Salinas Laura Prieto-Pérez Miguel Górgolas-Hernández Martin Casapía-Morales |
| author_facet | José-Manuel Ramos-Rincón Sonia Ortiz-Martínez María-Esteyner Vásquez-Chasnamote Eva de-Miguel-Balsa Olga-Nohelia Gamboa-Paredes Michael-John Talledo-Albujar Giovanni López-Campana Juan Carlos Celis-Salinas Laura Prieto-Pérez Miguel Górgolas-Hernández Martin Casapía-Morales |
| author_sort | José-Manuel Ramos-Rincón |
| collection | DOAJ |
| description | <b>Background</b>. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. <b>(2) Methods</b>. This is a prospective cross-sectional study involving pregnant women attending health centers in the city of Iquitos, Peru, in May and June 2019. The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). Positive cases were confirmed by Western Blot and HTLV-1 proviral load. <b>(3) Results</b>. The study included 300 pregnant women with a mean age of 26 years (standard deviation [SD] 6.4). Five patients were diagnosed with HTLV-1 infection (prevalence 1.7%, 95% confidence interval (CI) 0.7% to 3.8%). Pregnant women with HTLV-1 infection were discretely younger (mean age 22.6 [SD 22.6] vs. 26.8 [SD 6.3]; <i>p</i> = 0.128). None of the five women had been transfused, and all were asymptomatic. Two (40%) also had a positive serology for <i>Strongyloides</i>, but larvae were not detected in any of the parasitological stool studies. The systematic review component identified 40 studies, which showed that the prevalence of <i>HTLV</i> infection in the general population was 2.9% (95% CI 1.2% to 5.3%) and in women of childbearing age, 2.5% (95% CI 1.2% to 4.0%). (4) Conclusion. The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. Screening for HTLV-1 in prenatal care is warranted. |
| first_indexed | 2024-03-09T00:33:29Z |
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| id | doaj.art-7242f4a44ed140559a3c854a2d10627d |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T00:33:29Z |
| publishDate | 2021-02-01 |
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| series | Pathogens |
| spelling | doaj.art-7242f4a44ed140559a3c854a2d10627d2023-12-11T18:19:50ZengMDPI AGPathogens2076-08172021-02-0110326010.3390/pathogens10030260Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in PeruJosé-Manuel Ramos-Rincón0Sonia Ortiz-Martínez1María-Esteyner Vásquez-Chasnamote2Eva de-Miguel-Balsa3Olga-Nohelia Gamboa-Paredes4Michael-John Talledo-Albujar5Giovanni López-Campana6Juan Carlos Celis-Salinas7Laura Prieto-Pérez8Miguel Górgolas-Hernández9Martin Casapía-Morales10Clinical Medicine Department, Miguel Hernández University of Elche & General University Hospital of Alicante, 03010 Alicante, SpainMedical Practice El Ballestero, Health Service of Castilla La Mancha, 02614 Albacete, SpainNatural Resources Research Center, Peruvian Amazon National University, Iquitos 16001, PeruClinical Medicine Department, Miguel Hernández University of Elche & General University Hospital of Elche, 03002 Alicante, SpainMedical Department, Amazon Rainforest Civil Association, Iquitos 16001, PeruVirology Unit, Institute of Tropical Medicine ‘Alexander von Humboldt’, Peruvian University Cayetano Heredia, Lima 15102, PeruVirology Unit, Institute of Tropical Medicine ‘Alexander von Humboldt’, Peruvian University Cayetano Heredia, Lima 15102, PeruInfectious Diseases and Tropical Medicine Service, Regional Hospital of Loreto & National University of the Peruvian Amazon, Iquitos 1600, PeruInfectious Diseases Division, University Hospital Foundation Jiménez Díaz & Autonomous University of Madrid, 28040 Madrid, SpainInfectious Diseases Division, University Hospital Foundation Jiménez Díaz & Autonomous University of Madrid, 28040 Madrid, SpainInfectious Diseases and Tropical Medicine Service, Regional Hospital of Loreto & National University of the Peruvian Amazon & Medical Department, Amazon Rainforest Civil Association, Iquitos 16001, Peru<b>Background</b>. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. <b>(2) Methods</b>. This is a prospective cross-sectional study involving pregnant women attending health centers in the city of Iquitos, Peru, in May and June 2019. The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). Positive cases were confirmed by Western Blot and HTLV-1 proviral load. <b>(3) Results</b>. The study included 300 pregnant women with a mean age of 26 years (standard deviation [SD] 6.4). Five patients were diagnosed with HTLV-1 infection (prevalence 1.7%, 95% confidence interval (CI) 0.7% to 3.8%). Pregnant women with HTLV-1 infection were discretely younger (mean age 22.6 [SD 22.6] vs. 26.8 [SD 6.3]; <i>p</i> = 0.128). None of the five women had been transfused, and all were asymptomatic. Two (40%) also had a positive serology for <i>Strongyloides</i>, but larvae were not detected in any of the parasitological stool studies. The systematic review component identified 40 studies, which showed that the prevalence of <i>HTLV</i> infection in the general population was 2.9% (95% CI 1.2% to 5.3%) and in women of childbearing age, 2.5% (95% CI 1.2% to 4.0%). (4) Conclusion. The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. Screening for HTLV-1 in prenatal care is warranted.https://www.mdpi.com/2076-0817/10/3/260HTLVprevalencepregnant womenPeruAmazonsystematic review |
| spellingShingle | José-Manuel Ramos-Rincón Sonia Ortiz-Martínez María-Esteyner Vásquez-Chasnamote Eva de-Miguel-Balsa Olga-Nohelia Gamboa-Paredes Michael-John Talledo-Albujar Giovanni López-Campana Juan Carlos Celis-Salinas Laura Prieto-Pérez Miguel Górgolas-Hernández Martin Casapía-Morales Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru Pathogens HTLV prevalence pregnant women Peru Amazon systematic review |
| title | Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru |
| title_full | Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru |
| title_fullStr | Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru |
| title_full_unstemmed | Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru |
| title_short | Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru |
| title_sort | screening for human t cell lymphotropic virus htlv in pregnant women in the peruvian amazon and systematic review with meta analysis of htlv infection in peru |
| topic | HTLV prevalence pregnant women Peru Amazon systematic review |
| url | https://www.mdpi.com/2076-0817/10/3/260 |
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