Transcriptome analysis in LRRK2 and idiopathic Parkinson’s disease at different glucose levels

Abstract Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson’s disease (PD). To detect potential effects of different glucose levels on gene expression, by RNA-seq we analyzed the transcriptome of dermal fibroblasts from idiopath...

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Bibliographic Details
Main Authors: Rubén Fernández-Santiago, Anna Esteve-Codina, Manel Fernández, Francesc Valldeoriola, Almudena Sanchez-Gómez, Esteban Muñoz, Yaroslau Compta, Eduardo Tolosa, Mario Ezquerra, María J. Martí
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-021-00255-x