The Geriatric Nutritional Risk Index Predicts Prognosis in Japanese Patients with LATITUDE High-Risk Metastatic Hormone-Sensitive Prostate Cancer: A Multi-Center Study
Malnutrition is associated with prognosis in cancer. The geriatric nutritional risk index (GNRI), based on the ratio of actual to ideal body weight and also serum albumin level, is a simple screening tool for assessing nutrition. We investigated the GNRI as a prognostic factor for oncological outcom...
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/22/5333 |
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| author | Taku Naiki Kiyoshi Takahara Hiromitsu Watanabe Keita Nakane Yosuke Sugiyama Takuya Koie Ryoichi Shiroki Hideaki Miyake Takahiro Yasui |
| author_facet | Taku Naiki Kiyoshi Takahara Hiromitsu Watanabe Keita Nakane Yosuke Sugiyama Takuya Koie Ryoichi Shiroki Hideaki Miyake Takahiro Yasui |
| author_sort | Taku Naiki |
| collection | DOAJ |
| description | Malnutrition is associated with prognosis in cancer. The geriatric nutritional risk index (GNRI), based on the ratio of actual to ideal body weight and also serum albumin level, is a simple screening tool for assessing nutrition. We investigated the GNRI as a prognostic factor for oncological outcomes in patients with high-risk metastatic hormone-sensitive prostate cancer (mHSPC) using a Japanese multicenter cohort. This study included a total of 175 patients with LATITUDE high-risk mHSPC, of whom 102 had received androgen deprivation therapy (ADT) plus upfront abiraterone acetate, and 73 had received ADT plus bicalutamide (Bica), from 14 institutions associated with the Tokai Urologic Oncology Research Seminar. Patients were classified into GNRI-low (<98) or GNRI-high (≥98) groups. The GNRI was based on the body mass index and serum albumin level. Kaplan–Meier analysis revealed that the median overall survival (OS) of a GNRI-low group (median 33.7 months; 95% confidence interval [CI]: 26.2–not reached [NR]) was significantly worse than that of a GNRI-high group (median: NR; 95% CI: NR–NR; <i>p</i> < 0.001). Multivariate analysis identified Bica and low GNRI (<98) as independent prognostic factors for reduced times to both castration-resistant prostate cancer and OS, and, therefore, a poor prognosis. Our findings indicate the GNRI may be a practical prognostic indicator in the evaluation of survival outcomes in patients with LATITUDE high-risk mHSPC. |
| first_indexed | 2024-03-09T16:57:41Z |
| format | Article |
| id | doaj.art-7246e14dc11e42b9ab6fd2826df2a586 |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T16:57:41Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7246e14dc11e42b9ab6fd2826df2a5862023-11-24T14:34:00ZengMDPI AGCancers2072-66942023-11-011522533310.3390/cancers15225333The Geriatric Nutritional Risk Index Predicts Prognosis in Japanese Patients with LATITUDE High-Risk Metastatic Hormone-Sensitive Prostate Cancer: A Multi-Center StudyTaku Naiki0Kiyoshi Takahara1Hiromitsu Watanabe2Keita Nakane3Yosuke Sugiyama4Takuya Koie5Ryoichi Shiroki6Hideaki Miyake7Takahiro Yasui8Department of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Urology, Fujita Medical University, Nagoya 470-1192, JapanDepartment of Urology, Hamamatsu University School of Medicine, Hamamatsu 431-3125, JapanDepartment of Urology, Gifu University, Gifu 501-1112, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Urology, Gifu University, Gifu 501-1112, JapanDepartment of Urology, Fujita Medical University, Nagoya 470-1192, JapanDepartment of Urology, Hamamatsu University School of Medicine, Hamamatsu 431-3125, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanMalnutrition is associated with prognosis in cancer. The geriatric nutritional risk index (GNRI), based on the ratio of actual to ideal body weight and also serum albumin level, is a simple screening tool for assessing nutrition. We investigated the GNRI as a prognostic factor for oncological outcomes in patients with high-risk metastatic hormone-sensitive prostate cancer (mHSPC) using a Japanese multicenter cohort. This study included a total of 175 patients with LATITUDE high-risk mHSPC, of whom 102 had received androgen deprivation therapy (ADT) plus upfront abiraterone acetate, and 73 had received ADT plus bicalutamide (Bica), from 14 institutions associated with the Tokai Urologic Oncology Research Seminar. Patients were classified into GNRI-low (<98) or GNRI-high (≥98) groups. The GNRI was based on the body mass index and serum albumin level. Kaplan–Meier analysis revealed that the median overall survival (OS) of a GNRI-low group (median 33.7 months; 95% confidence interval [CI]: 26.2–not reached [NR]) was significantly worse than that of a GNRI-high group (median: NR; 95% CI: NR–NR; <i>p</i> < 0.001). Multivariate analysis identified Bica and low GNRI (<98) as independent prognostic factors for reduced times to both castration-resistant prostate cancer and OS, and, therefore, a poor prognosis. Our findings indicate the GNRI may be a practical prognostic indicator in the evaluation of survival outcomes in patients with LATITUDE high-risk mHSPC.https://www.mdpi.com/2072-6694/15/22/5333abiraterone acetateagedandrogen antagonistsbicalutamidenutrition assessment |
| spellingShingle | Taku Naiki Kiyoshi Takahara Hiromitsu Watanabe Keita Nakane Yosuke Sugiyama Takuya Koie Ryoichi Shiroki Hideaki Miyake Takahiro Yasui The Geriatric Nutritional Risk Index Predicts Prognosis in Japanese Patients with LATITUDE High-Risk Metastatic Hormone-Sensitive Prostate Cancer: A Multi-Center Study Cancers abiraterone acetate aged androgen antagonists bicalutamide nutrition assessment |
| title | The Geriatric Nutritional Risk Index Predicts Prognosis in Japanese Patients with LATITUDE High-Risk Metastatic Hormone-Sensitive Prostate Cancer: A Multi-Center Study |
| title_full | The Geriatric Nutritional Risk Index Predicts Prognosis in Japanese Patients with LATITUDE High-Risk Metastatic Hormone-Sensitive Prostate Cancer: A Multi-Center Study |
| title_fullStr | The Geriatric Nutritional Risk Index Predicts Prognosis in Japanese Patients with LATITUDE High-Risk Metastatic Hormone-Sensitive Prostate Cancer: A Multi-Center Study |
| title_full_unstemmed | The Geriatric Nutritional Risk Index Predicts Prognosis in Japanese Patients with LATITUDE High-Risk Metastatic Hormone-Sensitive Prostate Cancer: A Multi-Center Study |
| title_short | The Geriatric Nutritional Risk Index Predicts Prognosis in Japanese Patients with LATITUDE High-Risk Metastatic Hormone-Sensitive Prostate Cancer: A Multi-Center Study |
| title_sort | geriatric nutritional risk index predicts prognosis in japanese patients with latitude high risk metastatic hormone sensitive prostate cancer a multi center study |
| topic | abiraterone acetate aged androgen antagonists bicalutamide nutrition assessment |
| url | https://www.mdpi.com/2072-6694/15/22/5333 |
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