From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia
In this review, we provide the state of the art about brain metastases (BMs) from gestational trophoblastic neoplasia (GTN), a rare condition. Data concerning the epidemiology, clinical presentation, innovations in therapeutic modalities, and outcomes of GTN BMs are comprehensively presented with pa...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.859071/full |
| _version_ | 1828413559889985536 |
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| author | Fulvio Borella Fulvio Borella Stefano Cosma Stefano Cosma Domenico Ferraioli Mario Preti Mario Preti Niccolò Gallio Niccolò Gallio Giorgio Valabrega Giulia Scotto Alessandro Rolfo Isabella Castellano Paola Cassoni Luca Bertero Chiara Benedetto Chiara Benedetto |
| author_facet | Fulvio Borella Fulvio Borella Stefano Cosma Stefano Cosma Domenico Ferraioli Mario Preti Mario Preti Niccolò Gallio Niccolò Gallio Giorgio Valabrega Giulia Scotto Alessandro Rolfo Isabella Castellano Paola Cassoni Luca Bertero Chiara Benedetto Chiara Benedetto |
| author_sort | Fulvio Borella |
| collection | DOAJ |
| description | In this review, we provide the state of the art about brain metastases (BMs) from gestational trophoblastic neoplasia (GTN), a rare condition. Data concerning the epidemiology, clinical presentation, innovations in therapeutic modalities, and outcomes of GTN BMs are comprehensively presented with particular attention to the role of radiotherapy, neurosurgery, and the most recent chemotherapy regimens. Good response rates have been achieved thanks to multi-agent chemotherapy, but brain involvement by GTNs entails significant risks for patients’ health since sudden and extensive intracranial hemorrhages are possible. Moreover, despite the evolution of treatment protocols, a small proportion of these patients ultimately develops a resistant disease. To tackle this unmet clinical need, immunotherapy has been recently proposed. The role of this novel option for this subset of patients as well as the achieved results so far are also discussed. |
| first_indexed | 2024-12-10T13:11:59Z |
| format | Article |
| id | doaj.art-72482af894034655a121d9eb317465cd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T13:11:59Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-72482af894034655a121d9eb317465cd2022-12-22T01:47:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.859071859071From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic NeoplasiaFulvio Borella0Fulvio Borella1Stefano Cosma2Stefano Cosma3Domenico Ferraioli4Mario Preti5Mario Preti6Niccolò Gallio7Niccolò Gallio8Giorgio Valabrega9Giulia Scotto10Alessandro Rolfo11Isabella Castellano12Paola Cassoni13Luca Bertero14Chiara Benedetto15Chiara Benedetto16Division of Gynecology and Obstetrics 1, “City of Health and Science University Hospital”, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyDivision of Gynecology and Obstetrics 1, “City of Health and Science University Hospital”, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyDepartment of Oncology Surgery, Centre Léon Berard (CLB), Lyon, FranceDivision of Gynecology and Obstetrics 1, “City of Health and Science University Hospital”, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyDivision of Gynecology and Obstetrics 1, “City of Health and Science University Hospital”, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyDepartment of Oncology, University of Torino, Torino, ItalyDepartment of Oncology, University of Torino, Torino, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyPathology Unit, Department of Medical Sciences, “City of Health and Science University Hospital”, University of Turin, Turin, ItalyPathology Unit, Department of Medical Sciences, “City of Health and Science University Hospital”, University of Turin, Turin, ItalyPathology Unit, Department of Medical Sciences, “City of Health and Science University Hospital”, University of Turin, Turin, ItalyDivision of Gynecology and Obstetrics 1, “City of Health and Science University Hospital”, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyIn this review, we provide the state of the art about brain metastases (BMs) from gestational trophoblastic neoplasia (GTN), a rare condition. Data concerning the epidemiology, clinical presentation, innovations in therapeutic modalities, and outcomes of GTN BMs are comprehensively presented with particular attention to the role of radiotherapy, neurosurgery, and the most recent chemotherapy regimens. Good response rates have been achieved thanks to multi-agent chemotherapy, but brain involvement by GTNs entails significant risks for patients’ health since sudden and extensive intracranial hemorrhages are possible. Moreover, despite the evolution of treatment protocols, a small proportion of these patients ultimately develops a resistant disease. To tackle this unmet clinical need, immunotherapy has been recently proposed. The role of this novel option for this subset of patients as well as the achieved results so far are also discussed.https://www.frontiersin.org/articles/10.3389/fonc.2022.859071/fullgestational trophoblastic neoplasiabrain metastases (BMs)choriocarcinomachemotherapyimmunotherapytreatment outcomes |
| spellingShingle | Fulvio Borella Fulvio Borella Stefano Cosma Stefano Cosma Domenico Ferraioli Mario Preti Mario Preti Niccolò Gallio Niccolò Gallio Giorgio Valabrega Giulia Scotto Alessandro Rolfo Isabella Castellano Paola Cassoni Luca Bertero Chiara Benedetto Chiara Benedetto From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia Frontiers in Oncology gestational trophoblastic neoplasia brain metastases (BMs) choriocarcinoma chemotherapy immunotherapy treatment outcomes |
| title | From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia |
| title_full | From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia |
| title_fullStr | From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia |
| title_full_unstemmed | From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia |
| title_short | From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia |
| title_sort | from uterus to brain an update on epidemiology clinical features and treatment of brain metastases from gestational trophoblastic neoplasia |
| topic | gestational trophoblastic neoplasia brain metastases (BMs) choriocarcinoma chemotherapy immunotherapy treatment outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.859071/full |
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