Defining the Immune Checkpoint Landscape in Human Colorectal Cancer Highlights the Relevance of the TIGIT/CD155 Axis for Optimizing Immunotherapy

Defining the Immune Checkpoint Landscape in Human Colorectal Cancer Highlights the Relevance of the TIGIT/CD155 Axis for Optimizing Immunotherapy

While immune checkpoint (IC) therapies, particularly those targeting the PD-1/PD-L1 axis, have revolutionized the treatment of melanoma and several other cancers, their effect remains very limited in colorectal cancer (CRC). To define a comprehensive landscape of ICs in the human CRC tumor microenvi...

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Bibliographic Details
Main Authors: Kathleen Ducoin, Linda Bilonda-Mutala, Cécile Deleine, Romain Oger, Emilie Duchalais, Nicolas Jouand, Céline Bossard, Anne Jarry, Nadine Gervois-Segain
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
immune checkpoints
TIGIT
tumor-infiltrating lymphocyte
colorectal cancer
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/14/17/4261

Internet

https://www.mdpi.com/2072-6694/14/17/4261

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