Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Stage Transition under Temperature Stress in Synchronized Plasmodium falciparum Cells

Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Stage Transition under Temperature Stress in Synchronized Plasmodium falciparum Cells

SUMMARY The malaria parasite has a complex life cycle exhibiting phenotypic and morphogenic variations in two different hosts by existing in heterogeneous developmental states. To investigate this cellular heterogeneity of the parasite within the human host, we performed single-cell RNA sequencing o...

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Bibliographic Details
Main Authors: Mukul Rawat, Ashish Srivastava, Shreya Johri, Ishaan Gupta, Krishanpal Karmodiya
Format: Article
Language:English
Published: American Society for Microbiology 2021-09-01
Series:Microbiology Spectrum
Subjects:
malaria
Plasmodium falciparum
antigenic variation
cellular heterogeneity
single-cell RNA sequencing
stress response
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00008-21

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