Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults
Purpose: To evaluate the impact of correct anatomical slab segmentation on foveal avascular zone (FAZ) dimensions in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA). Methods: Participants with healthy retinas were recruited...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-06-01
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| Series: | Journal of Current Ophthalmology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452232517302391 |
| _version_ | 1818942777140969472 |
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| author | Felix Rommel Fynn Siegfried Maximilian Kurz Max Philipp Brinkmann Matthias Rothe Martin Rudolf Salvatore Grisanti Mahdy Ranjbar |
| author_facet | Felix Rommel Fynn Siegfried Maximilian Kurz Max Philipp Brinkmann Matthias Rothe Martin Rudolf Salvatore Grisanti Mahdy Ranjbar |
| author_sort | Felix Rommel |
| collection | DOAJ |
| description | Purpose: To evaluate the impact of correct anatomical slab segmentation on foveal avascular zone (FAZ) dimensions in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA). Methods: Participants with healthy retinas were recruited, and 5 × 5 mm OCTA images were acquired using the Canon HS-100 Angio eXpert module. FAZ size was measured in automatically (AS, manufacturer-based) and manually (MS, anatomical-based) segmented OCTA slabs by two experienced graders. FAZ dimensions, inter-rater agreement, and correlation to demographic and retinal parameters were evaluated. Results: A total of 38 eyes from 20 healthy adult subjects were included in this cross-sectional study. While in AS slabs, the FAZ in the SCP was smaller than in the DCP, in MS images, it was the opposite. MS had a relevant impact on inter-rater agreement of FAZ measurements in the SCP. The FAZ area in both plexus correlated inversely with the central retinal thickness (CRT), irrespective of the segmentation applied. Furthermore, an enlargement of FAZ size in the DCP with increasing age was found. Finally, the FAZ in female participants was significantly larger than in their male counterparts, regardless of the evaluated plexus and chosen segmentation. Conclusions: Correct anatomical slab segmentation has a significant impact on FAZ size measurements. Not adjusting the segmentation boundaries represents a significant source of error for measuring FAZ area and confounds comparisons across studies as well as OCTA devices. Keywords: Foveal avascular zone, Optical coherence tomography, Optical coherence tomography angiography, Slab segmentation |
| first_indexed | 2024-12-20T07:16:49Z |
| format | Article |
| id | doaj.art-724bdb4a29f1452cba5ea01c9fc8af4c |
| institution | Directory Open Access Journal |
| issn | 2452-2325 |
| language | English |
| last_indexed | 2024-12-20T07:16:49Z |
| publishDate | 2018-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Ophthalmology |
| spelling | doaj.art-724bdb4a29f1452cba5ea01c9fc8af4c2022-12-21T19:48:46ZengWolters Kluwer Medknow PublicationsJournal of Current Ophthalmology2452-23252018-06-01302156160Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adultsFelix Rommel0Fynn Siegfried1Maximilian Kurz2Max Philipp Brinkmann3Matthias Rothe4Martin Rudolf5Salvatore Grisanti6Mahdy Ranjbar7Department of Ophthalmology, Augenklinik - Universität zu Lübeck, Germany; Laboratory for Angiogenesis & Ocular Cell Transplantation, Lübeck, Germany; Corresponding author: RatzeburgerAllee 160, 23538 Lübeck, Germany.Laboratory for Angiogenesis & Ocular Cell Transplantation, Lübeck, GermanyDepartment of Ophthalmology, Augenklinik - Universität zu Lübeck, Germany; Laboratory for Angiogenesis & Ocular Cell Transplantation, Lübeck, GermanyDepartment of Ophthalmology, Augenklinik - Universität zu Lübeck, Germany; Laboratory for Angiogenesis & Ocular Cell Transplantation, Lübeck, GermanyDepartment of Ophthalmology, Augenklinik - Universität zu Lübeck, Germany; Laboratory for Angiogenesis & Ocular Cell Transplantation, Lübeck, GermanyDepartment of Ophthalmology, Augenklinik - Universität zu Lübeck, GermanyDepartment of Ophthalmology, Augenklinik - Universität zu Lübeck, GermanyDepartment of Ophthalmology, Augenklinik - Universität zu Lübeck, Germany; Laboratory for Angiogenesis & Ocular Cell Transplantation, Lübeck, GermanyPurpose: To evaluate the impact of correct anatomical slab segmentation on foveal avascular zone (FAZ) dimensions in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA). Methods: Participants with healthy retinas were recruited, and 5 × 5 mm OCTA images were acquired using the Canon HS-100 Angio eXpert module. FAZ size was measured in automatically (AS, manufacturer-based) and manually (MS, anatomical-based) segmented OCTA slabs by two experienced graders. FAZ dimensions, inter-rater agreement, and correlation to demographic and retinal parameters were evaluated. Results: A total of 38 eyes from 20 healthy adult subjects were included in this cross-sectional study. While in AS slabs, the FAZ in the SCP was smaller than in the DCP, in MS images, it was the opposite. MS had a relevant impact on inter-rater agreement of FAZ measurements in the SCP. The FAZ area in both plexus correlated inversely with the central retinal thickness (CRT), irrespective of the segmentation applied. Furthermore, an enlargement of FAZ size in the DCP with increasing age was found. Finally, the FAZ in female participants was significantly larger than in their male counterparts, regardless of the evaluated plexus and chosen segmentation. Conclusions: Correct anatomical slab segmentation has a significant impact on FAZ size measurements. Not adjusting the segmentation boundaries represents a significant source of error for measuring FAZ area and confounds comparisons across studies as well as OCTA devices. Keywords: Foveal avascular zone, Optical coherence tomography, Optical coherence tomography angiography, Slab segmentationhttp://www.sciencedirect.com/science/article/pii/S2452232517302391 |
| spellingShingle | Felix Rommel Fynn Siegfried Maximilian Kurz Max Philipp Brinkmann Matthias Rothe Martin Rudolf Salvatore Grisanti Mahdy Ranjbar Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults Journal of Current Ophthalmology |
| title | Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults |
| title_full | Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults |
| title_fullStr | Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults |
| title_full_unstemmed | Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults |
| title_short | Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults |
| title_sort | impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults |
| url | http://www.sciencedirect.com/science/article/pii/S2452232517302391 |
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