Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I
Respiratory complex I inhibition by drugs and other chemicals has been implicated as a frequent mode of mitochondria-mediated cell injury. However, the exact mechanisms leading to the activation of cell death pathways are incompletely understood. This study was designed to explore the relative contr...
Main Authors: | Naoki Imaizumi, Kang Kwang Lee, Carmen Zhang, Urs A. Boelsterli |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015-04-01
|
Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231715000063 |
Similar Items
-
Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes
by: Kang Kwang Lee, et al.
Published: (2014-01-01) -
Daño hepático inducido por medicamentos: relación entre el índice R y la histopatología
by: O.M. Ardila-Suárez, et al.
Published: (2023-01-01) -
Drug-induced liver injury: Relation between the R ratio and histopathology
by: O.M. Ardila-Suárez, et al.
Published: (2023-01-01) -
A Small-Molecule Fluorescent Probe for the Detection of Mitochondrial Peroxynitrite
by: Han Dong, et al.
Published: (2023-12-01) -
Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases
by: Yunxia Luo, et al.
Published: (2021-04-01)