MicroRNA and Pathogenesis of Enterovirus Infection
There are no currently available specific antiviral therapies for non-polio Enterovirus infections. Although several vaccines have entered clinical trials, the efficacy requires further evaluation, particularly for cross-strain protective activity. Curing patients with viral infections is a public h...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-01-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/8/1/11 |
| _version_ | 1830287885027246080 |
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| author | Bing-Ching Ho Pan-Chyr Yang Sung-Liang Yu |
| author_facet | Bing-Ching Ho Pan-Chyr Yang Sung-Liang Yu |
| author_sort | Bing-Ching Ho |
| collection | DOAJ |
| description | There are no currently available specific antiviral therapies for non-polio Enterovirus infections. Although several vaccines have entered clinical trials, the efficacy requires further evaluation, particularly for cross-strain protective activity. Curing patients with viral infections is a public health problem due to antigen alterations and drug resistance caused by the high genomic mutation rate. To conquer these limits in the development of anti-Enterovirus treatments, a comprehensive understanding of the interactions between Enterovirus and host cells is urgently needed. MicroRNA (miRNA) constitutes the biggest family of gene regulators in mammalian cells and regulates almost a half of all human genes. The roles of miRNAs in Enterovirus pathogenesis have recently begun to be noted. In this review, we shed light on recent advances in the understanding of Enterovirus infection-modulated miRNAs. The impacts of altered host miRNAs on cellular processes, including immune escape, apoptosis, signal transduction, shutdown of host protein synthesis and viral replication, are discussed. Finally, miRNA-based medication provides a promising strategy for the development of antiviral therapy. |
| first_indexed | 2024-12-19T04:25:32Z |
| format | Article |
| id | doaj.art-724d0dd5f7f342c38ec0fdffed0b7385 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-19T04:25:32Z |
| publishDate | 2016-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-724d0dd5f7f342c38ec0fdffed0b73852022-12-21T20:36:01ZengMDPI AGViruses1999-49152016-01-01811110.3390/v8010011v8010011MicroRNA and Pathogenesis of Enterovirus InfectionBing-Ching Ho0Pan-Chyr Yang1Sung-Liang Yu2Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 10048, TaiwanCenter of Genomic Medicine, National Taiwan University, Taipei 10048, TaiwanDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 10048, TaiwanThere are no currently available specific antiviral therapies for non-polio Enterovirus infections. Although several vaccines have entered clinical trials, the efficacy requires further evaluation, particularly for cross-strain protective activity. Curing patients with viral infections is a public health problem due to antigen alterations and drug resistance caused by the high genomic mutation rate. To conquer these limits in the development of anti-Enterovirus treatments, a comprehensive understanding of the interactions between Enterovirus and host cells is urgently needed. MicroRNA (miRNA) constitutes the biggest family of gene regulators in mammalian cells and regulates almost a half of all human genes. The roles of miRNAs in Enterovirus pathogenesis have recently begun to be noted. In this review, we shed light on recent advances in the understanding of Enterovirus infection-modulated miRNAs. The impacts of altered host miRNAs on cellular processes, including immune escape, apoptosis, signal transduction, shutdown of host protein synthesis and viral replication, are discussed. Finally, miRNA-based medication provides a promising strategy for the development of antiviral therapy.http://www.mdpi.com/1999-4915/8/1/11non-coding RNAmicroRNAapoptosisprotein synthesis shutdownvirus replication |
| spellingShingle | Bing-Ching Ho Pan-Chyr Yang Sung-Liang Yu MicroRNA and Pathogenesis of Enterovirus Infection Viruses non-coding RNA microRNA apoptosis protein synthesis shutdown virus replication |
| title | MicroRNA and Pathogenesis of Enterovirus Infection |
| title_full | MicroRNA and Pathogenesis of Enterovirus Infection |
| title_fullStr | MicroRNA and Pathogenesis of Enterovirus Infection |
| title_full_unstemmed | MicroRNA and Pathogenesis of Enterovirus Infection |
| title_short | MicroRNA and Pathogenesis of Enterovirus Infection |
| title_sort | microrna and pathogenesis of enterovirus infection |
| topic | non-coding RNA microRNA apoptosis protein synthesis shutdown virus replication |
| url | http://www.mdpi.com/1999-4915/8/1/11 |
| work_keys_str_mv | AT bingchingho micrornaandpathogenesisofenterovirusinfection AT panchyryang micrornaandpathogenesisofenterovirusinfection AT sungliangyu micrornaandpathogenesisofenterovirusinfection |