Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors
This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal anti-inflammatory drugs (NSAIDs) in the management of AD. In addition to COX-2 enzymes role in inflammation, the format...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423002244 |
| _version_ | 1797689500674031616 |
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| author | Nathalie Moussa Ninar Dayoub |
| author_facet | Nathalie Moussa Ninar Dayoub |
| author_sort | Nathalie Moussa |
| collection | DOAJ |
| description | This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal anti-inflammatory drugs (NSAIDs) in the management of AD. In addition to COX-2 enzymes role in inflammation, the formation of amyloid plaques and neurofibrillary tangles in the brain, the review emphasizes that COXs-2 have a crucial role in normal synaptic activity and plasticity, and have a relationship with acetylcholine, tau protein, and beta-amyloid (Aβ) which are the main causes of Alzheimer's disease. Furthermore, the review points out that COX-2 enzymes have a relationship with kinase enzymes, including Cyclin Dependent Kinase 5 (CDK5) and Glycogen Synthase Kinase 3β (GSK3β), which are known to play a role in tau phosphorylation and are strongly associated with Alzheimer's disease. Therefore, the use of drugs like NSAIDs may be a hopeful approach for managing AD.However, results from studies examining the effectiveness of NSAIDs in treating AD have been mixed and further research is needed to fully understand the mechanisms by which COX-2 and NSAIDs may be involved in the development and progression of AD and to identify new therapeutic strategies. |
| first_indexed | 2024-03-12T01:47:27Z |
| format | Article |
| id | doaj.art-724e6887b4e44614bf309638c74398cf |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-03-12T01:47:27Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-724e6887b4e44614bf309638c74398cf2023-09-09T04:54:43ZengElsevierSaudi Pharmaceutical Journal1319-01642023-09-01319101729Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitorsNathalie Moussa0Ninar Dayoub1Department of Pharmaceutical Chemistry and Drug Control, University of Manara, Latakia, Syria; Corresponding author.Faculty of Pharmacy, University of AL Andalus for Medical Science, Tartus, SyriaThis review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal anti-inflammatory drugs (NSAIDs) in the management of AD. In addition to COX-2 enzymes role in inflammation, the formation of amyloid plaques and neurofibrillary tangles in the brain, the review emphasizes that COXs-2 have a crucial role in normal synaptic activity and plasticity, and have a relationship with acetylcholine, tau protein, and beta-amyloid (Aβ) which are the main causes of Alzheimer's disease. Furthermore, the review points out that COX-2 enzymes have a relationship with kinase enzymes, including Cyclin Dependent Kinase 5 (CDK5) and Glycogen Synthase Kinase 3β (GSK3β), which are known to play a role in tau phosphorylation and are strongly associated with Alzheimer's disease. Therefore, the use of drugs like NSAIDs may be a hopeful approach for managing AD.However, results from studies examining the effectiveness of NSAIDs in treating AD have been mixed and further research is needed to fully understand the mechanisms by which COX-2 and NSAIDs may be involved in the development and progression of AD and to identify new therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S1319016423002244Alzheimer's diseaseCOX-2NSAIDsDrug discoveryCDK5Tau phosphorylation |
| spellingShingle | Nathalie Moussa Ninar Dayoub Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors Saudi Pharmaceutical Journal Alzheimer's disease COX-2 NSAIDs Drug discovery CDK5 Tau phosphorylation |
| title | Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors |
| title_full | Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors |
| title_fullStr | Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors |
| title_full_unstemmed | Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors |
| title_short | Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors |
| title_sort | exploring the role of cox 2 in alzheimer s disease potential therapeutic implications of cox 2 inhibitors |
| topic | Alzheimer's disease COX-2 NSAIDs Drug discovery CDK5 Tau phosphorylation |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423002244 |
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