Hepatoprotective effect of opioid peptides in stress
Introduction: Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress-susceptible animals. Materi...
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2019-03-01
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| Series: | Research Results in Pharmacology |
| Online Access: | https://rrpharmacology.pensoft.net/article/34472/download/pdf/ |
| _version_ | 1827616865410613248 |
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| author | Alexey V. Solin Yury D. Lyashev Nikolay V. Tsygan |
| author_facet | Alexey V. Solin Yury D. Lyashev Nikolay V. Tsygan |
| author_sort | Alexey V. Solin |
| collection | DOAJ |
| description | Introduction: Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress-susceptible animals.
Materials and methods: The investigation was performed on 725 Wistar male-rats. Various types of stress were modeled: acute immobilization stress of various duration (3, 6 and 12 hours), chronic stress of limited mobility, swimming stress and traumatic stress (resection of 70% of the liver). Agonists of various types of opioid receptors in equimolar doses were injected to stressed animals at equimolar doses: DAGO – a mu-receptor agonist – at a dose of 6.3 mcg/kg, DSLET – a delta-receptor agonist – at a dose of 10 mcg/kg, and kappa receptor agonist dynorphin A (1-13) – at a dose of 20.1 mcg/kg.
Results and discussion: The stress-limiting action of the studied opioids is characterized by the reduced hepatocyte dystrophy, microcirculation correction, a decreased concentration of lipid peroxidation metabolites, a suppressed cytolytic syndrome, a stimulated synthetic ability of the liver, and is more pronounced in stress- susceptible animals. The greatest stress-protective effect is shown after administering dynorphin A (1-13) in immobilization stress, and DAGO – in swimming stress. Dynorphin A (1-13) and DAGO manifested the most pronounced effect on the liver regeneration after resection. A preliminary stress simulation accelerates liver regeneration at the initial stage after resection.
Conclusion: The hepatoprotective effect of opioids in stress depends on the typological peculiarities of animals. The results obtained offer a challenge of synthesizing new hepatoprotectors. |
| first_indexed | 2024-03-09T09:33:55Z |
| format | Article |
| id | doaj.art-725219d76c8d471cbfb8d7bb57dab0c5 |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:33:55Z |
| publishDate | 2019-03-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-725219d76c8d471cbfb8d7bb57dab0c52023-12-02T02:42:21ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2019-03-0151779610.3897/rrpharmacology.5.3447234472Hepatoprotective effect of opioid peptides in stressAlexey V. Solin0Yury D. Lyashev1Nikolay V. Tsygan2Kursk State Medical UniversityKursk State Medical UniversityB.P. Konstantinov Petersburg Nuclear Physics InstituteIntroduction: Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress-susceptible animals. Materials and methods: The investigation was performed on 725 Wistar male-rats. Various types of stress were modeled: acute immobilization stress of various duration (3, 6 and 12 hours), chronic stress of limited mobility, swimming stress and traumatic stress (resection of 70% of the liver). Agonists of various types of opioid receptors in equimolar doses were injected to stressed animals at equimolar doses: DAGO – a mu-receptor agonist – at a dose of 6.3 mcg/kg, DSLET – a delta-receptor agonist – at a dose of 10 mcg/kg, and kappa receptor agonist dynorphin A (1-13) – at a dose of 20.1 mcg/kg. Results and discussion: The stress-limiting action of the studied opioids is characterized by the reduced hepatocyte dystrophy, microcirculation correction, a decreased concentration of lipid peroxidation metabolites, a suppressed cytolytic syndrome, a stimulated synthetic ability of the liver, and is more pronounced in stress- susceptible animals. The greatest stress-protective effect is shown after administering dynorphin A (1-13) in immobilization stress, and DAGO – in swimming stress. Dynorphin A (1-13) and DAGO manifested the most pronounced effect on the liver regeneration after resection. A preliminary stress simulation accelerates liver regeneration at the initial stage after resection. Conclusion: The hepatoprotective effect of opioids in stress depends on the typological peculiarities of animals. The results obtained offer a challenge of synthesizing new hepatoprotectors.https://rrpharmacology.pensoft.net/article/34472/download/pdf/ |
| spellingShingle | Alexey V. Solin Yury D. Lyashev Nikolay V. Tsygan Hepatoprotective effect of opioid peptides in stress Research Results in Pharmacology |
| title | Hepatoprotective effect of opioid peptides in stress |
| title_full | Hepatoprotective effect of opioid peptides in stress |
| title_fullStr | Hepatoprotective effect of opioid peptides in stress |
| title_full_unstemmed | Hepatoprotective effect of opioid peptides in stress |
| title_short | Hepatoprotective effect of opioid peptides in stress |
| title_sort | hepatoprotective effect of opioid peptides in stress |
| url | https://rrpharmacology.pensoft.net/article/34472/download/pdf/ |
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