Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum

Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum

Abstract Background Oxaloacetate (OAA) and l-glutamate are essential precursors for the biosynthesis of l-lysine. Reasonable control of all potentially rate-limiting steps, including the precursors supply rate, is of vital importance to maximize the efficiency of l-lysine fermentation process. Resul...

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Bibliographic Details
Main Authors: Jian-Zhong Xu, Ze-Hua Wu, Shi-Jun Gao, Weiguo Zhang
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Microbial Cell Factories
Subjects:
Corynebacterium glutamicum
l-Lysine production
Phosphoenolpyruvate–pyruvate–oxaloacetate node
Tricarboxylate synthase
Glutamate dehydrogenase
Biotin
Online Access:http://link.springer.com/article/10.1186/s12934-018-0958-z

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