Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors
Being one of the leading causes of cancer deaths worldwide and their resistance to conventional treatment methods, made gastrointestinal stromal tumors (GISTs) one of the hot topics in medical research areas in the past decade. To investigate molecular alterations underlying the tumor is of great im...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2021-07-01
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| Series: | Balkan Journal of Medical Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/bjmg-2021-0006 |
| _version_ | 1797705327299264512 |
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| author | Ozkayalar H Ergoren MC Tuncel G Kurt S Cevik E Ozemri Sag S Yilmaz Ozguven B Kabukcuoglu F Mocan G Temel ŞG |
| author_facet | Ozkayalar H Ergoren MC Tuncel G Kurt S Cevik E Ozemri Sag S Yilmaz Ozguven B Kabukcuoglu F Mocan G Temel ŞG |
| author_sort | Ozkayalar H |
| collection | DOAJ |
| description | Being one of the leading causes of cancer deaths worldwide and their resistance to conventional treatment methods, made gastrointestinal stromal tumors (GISTs) one of the hot topics in medical research areas in the past decade. To investigate molecular alterations underlying the tumor is of great importance to be able to develop new, targeted treatment options. In this study, GIST samples obtained from 40 Turkish patients were analyzed for actionable epidermal growth factor receptor (EGFR) mutations that are related to treatment regimes in non small cell lung cancer (NSCLC) to understand whether EGFR expression is altered in GISTs. Established alterations in EGFR can make the use of tyrosine kinase inhibitors possible, which are currently used in cancer therapy, especially in NSCLC. Our results indicated that EGFR mutations are rare in GISTs. Further research is needed to sequence whole coding regions of the gene to investigate new actionable mutations in EGFR in an increased sample size. |
| first_indexed | 2024-03-12T05:34:29Z |
| format | Article |
| id | doaj.art-725448a1f3424eb5857da28af2a37792 |
| institution | Directory Open Access Journal |
| issn | 1311-0160 |
| language | English |
| last_indexed | 2024-03-12T05:34:29Z |
| publishDate | 2021-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Balkan Journal of Medical Genetics |
| spelling | doaj.art-725448a1f3424eb5857da28af2a377922023-09-03T06:32:21ZengSciendoBalkan Journal of Medical Genetics1311-01602021-07-01241677210.2478/bjmg-2021-0006Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumorsOzkayalar H0Ergoren MC1Tuncel G2Kurt S3Cevik E4Ozemri Sag S5Yilmaz Ozguven B6Kabukcuoglu F7Mocan G8Temel ŞG9Department of Pathology, Faculty of Medicine, Near East University, Northern Nicosia, CyprusDepartment of Medical Biology, Faculty of Medicine, Near East University, Northern Nicosia, CyprusDepartment of Medical Biology, Faculty of Medicine, Near East University, Northern Nicosia, CyprusDepartment of Medical Genetics, Faculty of Medicine, Bursa Uludag University, Bursa, TurkeyDepartment of Medical Genetics, Faculty of Medicine, Bursa Uludag University, Bursa, TurkeyDepartment of Medical Genetics, Faculty of Medicine, Bursa Uludag University, Bursa, TurkeyDepartment of Pathology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Sciences, İstanbul, TurkeyDepartment of Pathology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Sciences, İstanbul, TurkeyDepartment of Pathology, Faculty of Medicine, Near East University, Northern Nicosia, CyprusDepartment of Medical Genetics, Faculty of Medicine, Bursa Uludag University, Bursa, TurkeyBeing one of the leading causes of cancer deaths worldwide and their resistance to conventional treatment methods, made gastrointestinal stromal tumors (GISTs) one of the hot topics in medical research areas in the past decade. To investigate molecular alterations underlying the tumor is of great importance to be able to develop new, targeted treatment options. In this study, GIST samples obtained from 40 Turkish patients were analyzed for actionable epidermal growth factor receptor (EGFR) mutations that are related to treatment regimes in non small cell lung cancer (NSCLC) to understand whether EGFR expression is altered in GISTs. Established alterations in EGFR can make the use of tyrosine kinase inhibitors possible, which are currently used in cancer therapy, especially in NSCLC. Our results indicated that EGFR mutations are rare in GISTs. Further research is needed to sequence whole coding regions of the gene to investigate new actionable mutations in EGFR in an increased sample size.https://doi.org/10.2478/bjmg-2021-0006epidermal growth factor receptor (egfr) genegastrointestinal stromal tumors (gists)targeted therapy |
| spellingShingle | Ozkayalar H Ergoren MC Tuncel G Kurt S Cevik E Ozemri Sag S Yilmaz Ozguven B Kabukcuoglu F Mocan G Temel ŞG Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors Balkan Journal of Medical Genetics epidermal growth factor receptor (egfr) gene gastrointestinal stromal tumors (gists) targeted therapy |
| title | Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors |
| title_full | Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors |
| title_fullStr | Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors |
| title_full_unstemmed | Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors |
| title_short | Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors |
| title_sort | mutation status and immunohistochemical correlation of egfr mutations in gastrointestinal stromal tumors |
| topic | epidermal growth factor receptor (egfr) gene gastrointestinal stromal tumors (gists) targeted therapy |
| url | https://doi.org/10.2478/bjmg-2021-0006 |
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