Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients
Abstract Background The variant of ALDH2 was thought to be associated with Acute Myocardial Infarction (AMI) due to the consumption of alcohol. This study focused on how ALDH2 variant acts as an independent risk factor for AMI, regardless of alcohol consumption. Methods and results We used the case–...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-022-02738-y |
| _version_ | 1811224241208557568 |
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| author | Qixia Jiang Xiaoguang Li Rukun Chen Chuhong Wang Xin Liu Xingyu Wang |
| author_facet | Qixia Jiang Xiaoguang Li Rukun Chen Chuhong Wang Xin Liu Xingyu Wang |
| author_sort | Qixia Jiang |
| collection | DOAJ |
| description | Abstract Background The variant of ALDH2 was thought to be associated with Acute Myocardial Infarction (AMI) due to the consumption of alcohol. This study focused on how ALDH2 variant acts as an independent risk factor for AMI, regardless of alcohol consumption. Methods and results We used the case–control INTERHEART-China study which took place at 25 centres in 17 cities in mainland China. Cases were patients with AMI and matched by age, sex, and site to controls. Information about alcohol consumption and genotype were collected. We divided cases and controls by alcohol consumption: alcohol intake group and no alcohol intake group. Then, calculated the Odd Ratio (OR) value with confidence interval (CI) at 95% level to find the association between ALDH2 variant and AMI. Results were then adjusted by sex, age, BMI, and other common risk factors of AMI. The study involves a total of 2660 controls and 2322 AMI patients. The no drink intake group showed that there was a correlation between the ALDH2 variant and AMI (OR = 1.236, 95% CI = 1.090–1.401, p = 0.00092). After adjustment of different risk factors this association remained (OR = 1.247, 95% CI = 1.099–1.415, p = 0.00062). Similar results were also obtained from the no alcohol intake group (OR = 1.196, 95% CI = 0.993–1.440, p = 0.05963), however, due to the limited sample size, the result was not significant enough statistically. Conclusion From our results, ALDH2 variant is associated with the risk of AMI even in population that has no alcohol consumption. This suggests that ALDH2 variant may act as an independent risk factor for AMI. |
| first_indexed | 2024-04-12T08:46:12Z |
| format | Article |
| id | doaj.art-725709a7d60f4120bbceb4d17d35d330 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-12T08:46:12Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-725709a7d60f4120bbceb4d17d35d3302022-12-22T03:39:42ZengBMCBMC Cardiovascular Disorders1471-22612022-07-012211710.1186/s12872-022-02738-yAssociation of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patientsQixia Jiang0Xiaoguang Li1Rukun Chen2Chuhong Wang3Xin Liu4Xingyu Wang5Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of General Surgery, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineDepartment of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of MedicineNational Center for Human Genetic Resources, National Research Institute for Family PlanningNational Center for Human Genetic Resources, National Research Institute for Family PlanningNational Center for Human Genetic Resources, National Research Institute for Family PlanningAbstract Background The variant of ALDH2 was thought to be associated with Acute Myocardial Infarction (AMI) due to the consumption of alcohol. This study focused on how ALDH2 variant acts as an independent risk factor for AMI, regardless of alcohol consumption. Methods and results We used the case–control INTERHEART-China study which took place at 25 centres in 17 cities in mainland China. Cases were patients with AMI and matched by age, sex, and site to controls. Information about alcohol consumption and genotype were collected. We divided cases and controls by alcohol consumption: alcohol intake group and no alcohol intake group. Then, calculated the Odd Ratio (OR) value with confidence interval (CI) at 95% level to find the association between ALDH2 variant and AMI. Results were then adjusted by sex, age, BMI, and other common risk factors of AMI. The study involves a total of 2660 controls and 2322 AMI patients. The no drink intake group showed that there was a correlation between the ALDH2 variant and AMI (OR = 1.236, 95% CI = 1.090–1.401, p = 0.00092). After adjustment of different risk factors this association remained (OR = 1.247, 95% CI = 1.099–1.415, p = 0.00062). Similar results were also obtained from the no alcohol intake group (OR = 1.196, 95% CI = 0.993–1.440, p = 0.05963), however, due to the limited sample size, the result was not significant enough statistically. Conclusion From our results, ALDH2 variant is associated with the risk of AMI even in population that has no alcohol consumption. This suggests that ALDH2 variant may act as an independent risk factor for AMI.https://doi.org/10.1186/s12872-022-02738-yAldehyde dehydrogenase 2 (ALDH2)Acute Myocardial Infarction (AMI)ChinaAlcohol consumptionPolymorphism |
| spellingShingle | Qixia Jiang Xiaoguang Li Rukun Chen Chuhong Wang Xin Liu Xingyu Wang Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients BMC Cardiovascular Disorders Aldehyde dehydrogenase 2 (ALDH2) Acute Myocardial Infarction (AMI) China Alcohol consumption Polymorphism |
| title | Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients |
| title_full | Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients |
| title_fullStr | Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients |
| title_full_unstemmed | Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients |
| title_short | Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients |
| title_sort | association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of chinese patients |
| topic | Aldehyde dehydrogenase 2 (ALDH2) Acute Myocardial Infarction (AMI) China Alcohol consumption Polymorphism |
| url | https://doi.org/10.1186/s12872-022-02738-y |
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