Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV

Objective: To report on the survival of a retinal pigment epithelium (RPE)-choroid graft translocated to treat a patient with drusenoid pigment epithelial detachment (DPED).Methods: We describe a patient with bilateral high-risk DPED where one eye was treated with RPE-choroid translocation surgery a...

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Main Authors: Sillen, Hedwig, Ruys, Joke, Schauwvlieghe, Pieter-Paul, Veckeneer, Marc
Format: Article
Language:English
Published: German Medical Science GMS Publishing House 2020-04-01
Series:GMS Ophthalmology Cases
Subjects:
Online Access:http://www.egms.de/static/en/journals/oc/2020-10/oc000151.shtml
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author Sillen, Hedwig
Ruys, Joke
Schauwvlieghe, Pieter-Paul
Veckeneer, Marc
author_facet Sillen, Hedwig
Ruys, Joke
Schauwvlieghe, Pieter-Paul
Veckeneer, Marc
author_sort Sillen, Hedwig
collection DOAJ
description Objective: To report on the survival of a retinal pigment epithelium (RPE)-choroid graft translocated to treat a patient with drusenoid pigment epithelial detachment (DPED).Methods: We describe a patient with bilateral high-risk DPED where one eye was treated with RPE-choroid translocation surgery and followed up for more than two years.Results: The RPE-choroid graft surgery was straightforward and the fully perfused graft was able to support stable vision of 0.5 Snellen acuity for more than two years despite the development of a choroidal neovessel at the edge of the graft. The vision in the fellow eye dropped from 0.5 to 0.2 Snellen in the same period.Conclusion: RPE-choroid translocation may slow the progression of DPED to atrophy but it can also transform dry age-related macular deeneration (AMD) into neovascular AMD.
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spelling doaj.art-7257f31884c348a8a4f690f4a4a01c702022-12-22T01:36:08ZengGerman Medical Science GMS Publishing HouseGMS Ophthalmology Cases2193-14962020-04-0110Doc2410.3205/oc000151Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNVSillen, Hedwig0Ruys, Joke1Schauwvlieghe, Pieter-Paul2Veckeneer, Marc3Department of Ophthalmology, Antwerp University Hospital, Edegem, BelgiumDepartment of Ophthalmology, ZNA Middelheim Hospital, Antwerp, BelgiumDepartment of Ophthalmology, ZNA Middelheim Hospital, Antwerp, BelgiumDepartment of Ophthalmology, ZNA Middelheim Hospital, Antwerp, BelgiumObjective: To report on the survival of a retinal pigment epithelium (RPE)-choroid graft translocated to treat a patient with drusenoid pigment epithelial detachment (DPED).Methods: We describe a patient with bilateral high-risk DPED where one eye was treated with RPE-choroid translocation surgery and followed up for more than two years.Results: The RPE-choroid graft surgery was straightforward and the fully perfused graft was able to support stable vision of 0.5 Snellen acuity for more than two years despite the development of a choroidal neovessel at the edge of the graft. The vision in the fellow eye dropped from 0.5 to 0.2 Snellen in the same period.Conclusion: RPE-choroid translocation may slow the progression of DPED to atrophy but it can also transform dry age-related macular deeneration (AMD) into neovascular AMD.http://www.egms.de/static/en/journals/oc/2020-10/oc000151.shtmlmacular degenerationretinal pigment epitheliumdrusenoid pigment epithelial detachmentrpe-choroid graft
spellingShingle Sillen, Hedwig
Ruys, Joke
Schauwvlieghe, Pieter-Paul
Veckeneer, Marc
Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV
GMS Ophthalmology Cases
macular degeneration
retinal pigment epithelium
drusenoid pigment epithelial detachment
rpe-choroid graft
title Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV
title_full Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV
title_fullStr Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV
title_full_unstemmed Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV
title_short Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV
title_sort autologous full thickness rpe choroid graft to treat high risk drusenoid pigment epithelial detachment without cnv
topic macular degeneration
retinal pigment epithelium
drusenoid pigment epithelial detachment
rpe-choroid graft
url http://www.egms.de/static/en/journals/oc/2020-10/oc000151.shtml
work_keys_str_mv AT sillenhedwig autologousfullthicknessrpechoroidgrafttotreathighriskdrusenoidpigmentepithelialdetachmentwithoutcnv
AT ruysjoke autologousfullthicknessrpechoroidgrafttotreathighriskdrusenoidpigmentepithelialdetachmentwithoutcnv
AT schauwvlieghepieterpaul autologousfullthicknessrpechoroidgrafttotreathighriskdrusenoidpigmentepithelialdetachmentwithoutcnv
AT veckeneermarc autologousfullthicknessrpechoroidgrafttotreathighriskdrusenoidpigmentepithelialdetachmentwithoutcnv