The therapeutic potential of natural products for treating pancreatic cancer
Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall surviva...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1051952/full |
| _version_ | 1797984552776368128 |
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| author | Xia He Ning Wang Yu Zhang Xiaobo Huang Yi Wang |
| author_facet | Xia He Ning Wang Yu Zhang Xiaobo Huang Yi Wang |
| author_sort | Xia He |
| collection | DOAJ |
| description | Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Panax Notoginseng Saponins and their metabolites etc. These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment. |
| first_indexed | 2024-04-11T07:03:27Z |
| format | Article |
| id | doaj.art-725b191c0d714bed860c4aeeabd324da |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T07:03:27Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-725b191c0d714bed860c4aeeabd324da2022-12-22T04:38:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10519521051952The therapeutic potential of natural products for treating pancreatic cancerXia He0Ning Wang1Yu Zhang2Xiaobo Huang3Yi Wang4Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Surgery, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaPancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Panax Notoginseng Saponins and their metabolites etc. These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment.https://www.frontiersin.org/articles/10.3389/fphar.2022.1051952/fullpancreatic cancernatural productscurcumintoosendanintriptolidepanax notoginseng saponins |
| spellingShingle | Xia He Ning Wang Yu Zhang Xiaobo Huang Yi Wang The therapeutic potential of natural products for treating pancreatic cancer Frontiers in Pharmacology pancreatic cancer natural products curcumin toosendanin triptolide panax notoginseng saponins |
| title | The therapeutic potential of natural products for treating pancreatic cancer |
| title_full | The therapeutic potential of natural products for treating pancreatic cancer |
| title_fullStr | The therapeutic potential of natural products for treating pancreatic cancer |
| title_full_unstemmed | The therapeutic potential of natural products for treating pancreatic cancer |
| title_short | The therapeutic potential of natural products for treating pancreatic cancer |
| title_sort | therapeutic potential of natural products for treating pancreatic cancer |
| topic | pancreatic cancer natural products curcumin toosendanin triptolide panax notoginseng saponins |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1051952/full |
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