Mechanisms of long non-coding RNAs in biological phenotypes and ferroptosis of glioma
Glioma, one of the most common malignant tumors in the nervous system, is characterized by limited treatment, high mortality and poor prognosis. Numerous studies have shown that lncRNAs play an important role in the onset and progression of glioma by acting on various classical signaling pathways of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.941327/full |
| _version_ | 1811224371663994880 |
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| author | Xianyong Yin Jiajia Gao Zihao Liu Min Han Xiaoshuai Ji Zhihai Wang Yuming Li Dong He Fenglin Zhang Qian Liu Tao Xin Tao Xin Tao Xin Tao Xin |
| author_facet | Xianyong Yin Jiajia Gao Zihao Liu Min Han Xiaoshuai Ji Zhihai Wang Yuming Li Dong He Fenglin Zhang Qian Liu Tao Xin Tao Xin Tao Xin Tao Xin |
| author_sort | Xianyong Yin |
| collection | DOAJ |
| description | Glioma, one of the most common malignant tumors in the nervous system, is characterized by limited treatment, high mortality and poor prognosis. Numerous studies have shown that lncRNAs play an important role in the onset and progression of glioma by acting on various classical signaling pathways of tumors through signaling, trapping, guiding, scaffolding and other functions. LncRNAs contribute to the malignant progression of glioma via proliferation, apoptosis, epithelial-mesenchymal transformation, chemotherapy resistance, ferroptosis and other biological traits. In this paper, relevant lncRNA signaling pathways involved in glioma progression were systematically evaluated, with emphasis placed on the specific molecular mechanism of lncRNAs in the process of ferroptosis, in order to provide a theoretical basis for the application of lncRNAs in the anticancer treatment of glioma. |
| first_indexed | 2024-04-12T08:48:27Z |
| format | Article |
| id | doaj.art-725b4065278e42b7a0ed9f5cc28965d0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T08:48:27Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-725b4065278e42b7a0ed9f5cc28965d02022-12-22T03:39:38ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.941327941327Mechanisms of long non-coding RNAs in biological phenotypes and ferroptosis of gliomaXianyong Yin0Jiajia Gao1Zihao Liu2Min Han3Xiaoshuai Ji4Zhihai Wang5Yuming Li6Dong He7Fenglin Zhang8Qian Liu9Tao Xin10Tao Xin11Tao Xin12Tao Xin13Department of Neurosurgery, Shandong Medicine and Health Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shandong Medicine and Health Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shandong Medicine and Health Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Histology and Embryology, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shandong Medicine and Health Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaGlioma, one of the most common malignant tumors in the nervous system, is characterized by limited treatment, high mortality and poor prognosis. Numerous studies have shown that lncRNAs play an important role in the onset and progression of glioma by acting on various classical signaling pathways of tumors through signaling, trapping, guiding, scaffolding and other functions. LncRNAs contribute to the malignant progression of glioma via proliferation, apoptosis, epithelial-mesenchymal transformation, chemotherapy resistance, ferroptosis and other biological traits. In this paper, relevant lncRNA signaling pathways involved in glioma progression were systematically evaluated, with emphasis placed on the specific molecular mechanism of lncRNAs in the process of ferroptosis, in order to provide a theoretical basis for the application of lncRNAs in the anticancer treatment of glioma.https://www.frontiersin.org/articles/10.3389/fonc.2022.941327/fulllncRNAsgliomaphenotypesferroptosismechanism |
| spellingShingle | Xianyong Yin Jiajia Gao Zihao Liu Min Han Xiaoshuai Ji Zhihai Wang Yuming Li Dong He Fenglin Zhang Qian Liu Tao Xin Tao Xin Tao Xin Tao Xin Mechanisms of long non-coding RNAs in biological phenotypes and ferroptosis of glioma Frontiers in Oncology lncRNAs glioma phenotypes ferroptosis mechanism |
| title | Mechanisms of long non-coding RNAs in biological phenotypes and ferroptosis of glioma |
| title_full | Mechanisms of long non-coding RNAs in biological phenotypes and ferroptosis of glioma |
| title_fullStr | Mechanisms of long non-coding RNAs in biological phenotypes and ferroptosis of glioma |
| title_full_unstemmed | Mechanisms of long non-coding RNAs in biological phenotypes and ferroptosis of glioma |
| title_short | Mechanisms of long non-coding RNAs in biological phenotypes and ferroptosis of glioma |
| title_sort | mechanisms of long non coding rnas in biological phenotypes and ferroptosis of glioma |
| topic | lncRNAs glioma phenotypes ferroptosis mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.941327/full |
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