Novel gold(I) complexes induce apoptosis in leukemia cells via the ROS-induced mitochondrial pathway with an upregulation of Harakiri and overcome multi drug resistances in leukemia and lymphoma cells and sensitize drug resistant tumor cells to apoptosis in vitro

Novel gold(I) complexes induce apoptosis in leukemia cells via the ROS-induced mitochondrial pathway with an upregulation of Harakiri and overcome multi drug resistances in leukemia and lymphoma cells and sensitize drug resistant tumor cells to apoptosis in vitro

Gold complexes could be promising for tumor therapy because of their cytotoxic and cytostatic properties. We present novel gold(I) complexes and clarify whether they also show antitumor activity by studying apoptosis induction in different tumor cell lines in vitro, comparing the compounds on resist...

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Bibliographic Details
Main Authors: Marie-C. Ahrweiler-Sawaryn, Animesh Biswas, Corazon Frias, Jerico Frias, Nicola L. Wilke, Nathalie Wilke, Albrecht Berkessel, Aram Prokop
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
NHC-Au(I) complexes
Mitochondrial pathway
Apoptosis
ROS
Bcl-2
Harakiri
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223002950

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