The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents
Abstract Background Brain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of the BDNF gene and is involved in the...
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| Format: | Article |
| Language: | English |
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Komiyama Printing Co. Ltd
2017-04-01
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| Series: | Environmental Health and Preventive Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12199-017-0643-6 |
| _version_ | 1818011346989481984 |
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| author | Yong Kyun Jeon Chang Ho Ha |
| author_facet | Yong Kyun Jeon Chang Ho Ha |
| author_sort | Yong Kyun Jeon |
| collection | DOAJ |
| description | Abstract Background Brain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of the BDNF gene and is involved in the growth and differentiation of neurons.Cortisol is released in response to stimuli such as psychological oppression, anxiety, and fear. Stress also induces changes in BDNF. The purpose of this study was thus to examine the effects of varying intensities of aerobic exercise on resting serum BDNF, IGF-1 concentrations, cortisol, and memory of adolescents. Methods Forty male students with no history of physical illness from the middle school by participated in this study. Participants were randomly assigned to low, moderate, or high intensity treadmill exercise group, or a stretching (control) group. Exercise was performed 4 times per week for 12 weeks. Body composition, brain derived neurotrophic factor levels, insulin-like growth factor 1 levels, cortisol levels, and working memory were assessed. Results The high intensity exercise group showed a significant increase in brain derived neurotrophic factor at rest, concentration level of insulin-like growth factor 1, cortisol, and working memory. For resting brain derived neurotrophic factor, the high intensity exercise group showed a more significant increase compared to the low intensity aerobic and stretching groups. The change in the working memory significantly increased for the high intensity exercise group compared to the low intensity aerobic group, moderate intensity exercise group, and stretching group. Conclusions In adolescents, whose brains are still developing, aerobic exercise of moderate to high intensity levels seems to have a positive effect on levels of serum brain derived neurotrophic factor at rest and on cognitive functioning. Trial registration EHPM-D-16-00107R2 . ICMJE. 12 July 2016. |
| first_indexed | 2024-04-14T06:06:32Z |
| format | Article |
| id | doaj.art-725df5c586c349ec97cd7f6dbd3cae60 |
| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-04-14T06:06:32Z |
| publishDate | 2017-04-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-725df5c586c349ec97cd7f6dbd3cae602022-12-22T02:08:30ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152017-04-012211610.1186/s12199-017-0643-6The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescentsYong Kyun Jeon0Chang Ho Ha1Department of Physical Education, Dankook UniversityDepartment Human Performance and Leisure Studies, North Carolina A&T State UniversityAbstract Background Brain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of the BDNF gene and is involved in the growth and differentiation of neurons.Cortisol is released in response to stimuli such as psychological oppression, anxiety, and fear. Stress also induces changes in BDNF. The purpose of this study was thus to examine the effects of varying intensities of aerobic exercise on resting serum BDNF, IGF-1 concentrations, cortisol, and memory of adolescents. Methods Forty male students with no history of physical illness from the middle school by participated in this study. Participants were randomly assigned to low, moderate, or high intensity treadmill exercise group, or a stretching (control) group. Exercise was performed 4 times per week for 12 weeks. Body composition, brain derived neurotrophic factor levels, insulin-like growth factor 1 levels, cortisol levels, and working memory were assessed. Results The high intensity exercise group showed a significant increase in brain derived neurotrophic factor at rest, concentration level of insulin-like growth factor 1, cortisol, and working memory. For resting brain derived neurotrophic factor, the high intensity exercise group showed a more significant increase compared to the low intensity aerobic and stretching groups. The change in the working memory significantly increased for the high intensity exercise group compared to the low intensity aerobic group, moderate intensity exercise group, and stretching group. Conclusions In adolescents, whose brains are still developing, aerobic exercise of moderate to high intensity levels seems to have a positive effect on levels of serum brain derived neurotrophic factor at rest and on cognitive functioning. Trial registration EHPM-D-16-00107R2 . ICMJE. 12 July 2016.http://link.springer.com/article/10.1186/s12199-017-0643-6Exercise intensityBDNFMemory |
| spellingShingle | Yong Kyun Jeon Chang Ho Ha The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents Environmental Health and Preventive Medicine Exercise intensity BDNF Memory |
| title | The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents |
| title_full | The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents |
| title_fullStr | The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents |
| title_full_unstemmed | The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents |
| title_short | The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents |
| title_sort | effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents |
| topic | Exercise intensity BDNF Memory |
| url | http://link.springer.com/article/10.1186/s12199-017-0643-6 |
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