Activation of the renin-angiotensin-aldosterone system in mares around ovulation
Many physiological events occurring during the estrous cycle, including folliculogenesis, oocyte maturation, ovulation, follicular atresia, corpus luteum development, luteolysis, steroidogenesis, and angiogenesis are associated with an increased expression of the renin-angiotensin-aldosterone system...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2017-06-01
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| Series: | Czech Journal of Animal Science |
| Subjects: | |
| Online Access: | https://cjas.agriculturejournals.cz/artkey/cjs-201706-0005_activation-of-the-renin-angiotensin-aldosterone-system-in-mares-around-ovulation.php |
| _version_ | 1797899191898341376 |
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| author | Katy Satué Paloma Montesinos Ana Muños |
| author_facet | Katy Satué Paloma Montesinos Ana Muños |
| author_sort | Katy Satué |
| collection | DOAJ |
| description | Many physiological events occurring during the estrous cycle, including folliculogenesis, oocyte maturation, ovulation, follicular atresia, corpus luteum development, luteolysis, steroidogenesis, and angiogenesis are associated with an increased expression of the renin-angiotensin-aldosterone system (RAAS) in uterus and ovarian follicles. This enhanced expression leads to a rise in plasma concentrations of these hormones in women and laboratory animals, and the same might happen in the mare. This study aims to assess if an activation of the RAAS occurs in mares around ovulation and if this activation is related to the diameter of the predominant follicle (DPF), packed cell volume (PCV), and electrolyte concentrations. Twenty-five healthy Spanish Purebred mares were sampled during the five days before ovulation, the day of ovulation, and the first five days after ovulation. Renin (REN) concentrations increased progressively during the five days before ovulation, achieving the highest values on the day of ovulation. Angiotensin (ANG) concentrations showed a sharp decrease after ovulation, with the lowest values the fifth day after it. Aldosterone (ALD) concentrations increased progressively, from the fifth day before ovulation until the fifth day after ovulation. The highest PCV values were found on the day of ovulation. There were no relevant correlations between the RAAS components and electrolytes concentrations. Before ovulation, there was a positive relationship between REN and ALD (r = 0.760) and after ovulation, a negative correlation between ANG and ALD (r = -0.660). The DPF was correlated with REN (r = 0.740) and with ALD (r = 0.800) concentrations. Ovulation in the mare is associated with high plasma REN concentrations, and therefore, with an activation of the RAAS. In addition, after ovulation, the sharp decrease in plasma REN and ANG concentrations might be a reflex of the modulation of the previously activated RAAS, although plasma ALD concentrations increased during this period. |
| first_indexed | 2024-04-10T08:25:07Z |
| format | Article |
| id | doaj.art-725f077d05be4e1ca5074738dc8f30fa |
| institution | Directory Open Access Journal |
| issn | 1212-1819 1805-9309 |
| language | English |
| last_indexed | 2024-04-10T08:25:07Z |
| publishDate | 2017-06-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Czech Journal of Animal Science |
| spelling | doaj.art-725f077d05be4e1ca5074738dc8f30fa2023-02-23T03:33:30ZengCzech Academy of Agricultural SciencesCzech Journal of Animal Science1212-18191805-93092017-06-0162625926710.17221/32/2016-CJAScjs-201706-0005Activation of the renin-angiotensin-aldosterone system in mares around ovulationKaty Satué0Paloma Montesinos1Ana Muños2Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Cardenal Herrera University, Valencia, SpainDepartment of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Cardenal Herrera University, Valencia, SpainEquine Sport Medicine Center CEMEDE, Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, SpainMany physiological events occurring during the estrous cycle, including folliculogenesis, oocyte maturation, ovulation, follicular atresia, corpus luteum development, luteolysis, steroidogenesis, and angiogenesis are associated with an increased expression of the renin-angiotensin-aldosterone system (RAAS) in uterus and ovarian follicles. This enhanced expression leads to a rise in plasma concentrations of these hormones in women and laboratory animals, and the same might happen in the mare. This study aims to assess if an activation of the RAAS occurs in mares around ovulation and if this activation is related to the diameter of the predominant follicle (DPF), packed cell volume (PCV), and electrolyte concentrations. Twenty-five healthy Spanish Purebred mares were sampled during the five days before ovulation, the day of ovulation, and the first five days after ovulation. Renin (REN) concentrations increased progressively during the five days before ovulation, achieving the highest values on the day of ovulation. Angiotensin (ANG) concentrations showed a sharp decrease after ovulation, with the lowest values the fifth day after it. Aldosterone (ALD) concentrations increased progressively, from the fifth day before ovulation until the fifth day after ovulation. The highest PCV values were found on the day of ovulation. There were no relevant correlations between the RAAS components and electrolytes concentrations. Before ovulation, there was a positive relationship between REN and ALD (r = 0.760) and after ovulation, a negative correlation between ANG and ALD (r = -0.660). The DPF was correlated with REN (r = 0.740) and with ALD (r = 0.800) concentrations. Ovulation in the mare is associated with high plasma REN concentrations, and therefore, with an activation of the RAAS. In addition, after ovulation, the sharp decrease in plasma REN and ANG concentrations might be a reflex of the modulation of the previously activated RAAS, although plasma ALD concentrations increased during this period.https://cjas.agriculturejournals.cz/artkey/cjs-201706-0005_activation-of-the-renin-angiotensin-aldosterone-system-in-mares-around-ovulation.phpestrousmarerenin-angiotensin-aldosterone system (raas) |
| spellingShingle | Katy Satué Paloma Montesinos Ana Muños Activation of the renin-angiotensin-aldosterone system in mares around ovulation Czech Journal of Animal Science estrous mare renin-angiotensin-aldosterone system (raas) |
| title | Activation of the renin-angiotensin-aldosterone system in mares around ovulation |
| title_full | Activation of the renin-angiotensin-aldosterone system in mares around ovulation |
| title_fullStr | Activation of the renin-angiotensin-aldosterone system in mares around ovulation |
| title_full_unstemmed | Activation of the renin-angiotensin-aldosterone system in mares around ovulation |
| title_short | Activation of the renin-angiotensin-aldosterone system in mares around ovulation |
| title_sort | activation of the renin angiotensin aldosterone system in mares around ovulation |
| topic | estrous mare renin-angiotensin-aldosterone system (raas) |
| url | https://cjas.agriculturejournals.cz/artkey/cjs-201706-0005_activation-of-the-renin-angiotensin-aldosterone-system-in-mares-around-ovulation.php |
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