Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
Background/Aims The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods This was a...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2020-01-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2018-137.pdf |
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| author | Kichul Shin Sung Soo Kim Sang-Heon Lee Seung-Jae Hong Sung Jae Choi Jung-Yoon Choe Seung-Geun Lee Hoon-Suk Cha Eun Young Lee Sung-Hwan Park Jin-Wuk Hur Sung Soo Na Chang-Hee Suh Min Wook So Seung Won Choi Dong-Hyuk Sheen Won Park Shin-Seok Lee Wan Hee Ryu Jin Seok Kim Jung Soo Song Hye Soon Lee Seong Ho Kim Dae-Hyun Yoo |
| author_facet | Kichul Shin Sung Soo Kim Sang-Heon Lee Seung-Jae Hong Sung Jae Choi Jung-Yoon Choe Seung-Geun Lee Hoon-Suk Cha Eun Young Lee Sung-Hwan Park Jin-Wuk Hur Sung Soo Na Chang-Hee Suh Min Wook So Seung Won Choi Dong-Hyuk Sheen Won Park Shin-Seok Lee Wan Hee Ryu Jin Seok Kim Jung Soo Song Hye Soon Lee Seong Ho Kim Dae-Hyun Yoo |
| author_sort | Kichul Shin |
| collection | DOAJ |
| description | Background/Aims The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods This was a nationwide multicenter observational study. Patients who had three or more active joint counts and abnormal inf lammatory marker in blood test were enrolled. The selection of DMARDs was determined by the attending rheumatologist. Clinical parameters, laboratory findings, and Health Assessment Questionnaire (HAQ) scores were obtained at baseline and at 6 and 12 months. Serial SDAI changes and clinical remission rate at 6 and 12 months were assessed. Results A total of 850 patients participated in this study. The mean baseline SDAI score in bDMARD group was higher than that in cDMARD group (32.08 ± 12.98 vs 25.69 ± 10.97, p < 0.0001). Mean change of SDAI at 12 months was –19.0 in the bDMARD group and –12.6 in the cDMARD group (p < 0.0001). Clinical remission rates at 12 months in bDMARD and cDMARD groups were 15.4% and 14.6%, respectively. Patient global assessment and HAQ at 12 months were also significantly improved in both groups. Multivariate logistic regression showed that baseline HAQ score was the most notable factor associated with remission. Conclusions There was a significant reduction in SDAI within 12 months after receiving DMARDs in Korean seropositive RA patients irrespective of bDMARD or cDMARD use in real-world practice. Clinical remission was achieved in those with lower baseline HAQ scores. |
| first_indexed | 2024-12-16T14:18:47Z |
| format | Article |
| id | doaj.art-725fdc8eea5442fcbdb582e832157469 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-16T14:18:47Z |
| publishDate | 2020-01-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-725fdc8eea5442fcbdb582e8321574692022-12-21T22:28:34ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-01-0135123123910.3904/kjim.2018.137170161Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activityKichul Shin0Sung Soo Kim1Sang-Heon Lee2Seung-Jae Hong3Sung Jae Choi4Jung-Yoon Choe5Seung-Geun Lee6Hoon-Suk Cha7Eun Young Lee8Sung-Hwan Park9Jin-Wuk Hur10Sung Soo Na11Chang-Hee Suh12Min Wook So13Seung Won Choi14Dong-Hyuk Sheen15Won Park16Shin-Seok Lee17Wan Hee Ryu18Jin Seok Kim19Jung Soo Song20Hye Soon Lee21Seong Ho Kim22Dae-Hyun Yoo23 Division of Rheumatology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea Division of Rheumatology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Division of Rheumatology, Konkuk University Medical Center, Seoul, Korea Division of Rheumatology, Kyung Hee University Hospital, Seoul, Korea Division of Rheumatology, Korea University Ansan Hospital, Ansan, Korea Division of Rheumatology, Daegu Catholic University Medical Center, Daegu, Korea Division of Rheumatology, Pusan National University Hospital, Busan, Korea Division of Rheumatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Rheumatology, Seoul National University Hospital, Seoul, Korea Division of Rheumatology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea Division of Rheumatology, Gangnam Eulji Hospital, Eulji University School of Medicine, Seoul, Korea Division of Rheumatology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea Division of Rheumatology, Ajou University Hospital, Suwon, Korea Division of Rheumatology, Pusan National University Yangsan Hospital, Yangsan, Korea Division of Rheumatology, Ulsan University Hospital, Ulsan, Korea Division of Rheumatology, Eulji University Hospital, Daejeon, Korea Division of Rheumatology, Inha University Hospital, Incheon, Korea Division of Rheumatology, Chonnam National University Hospital, Gwangju, Korea Division of Rheumatology, Chonbuk National University Hospital, Jeonju, Korea Division of Rheumatology, Jeju National University Hospital, Jeju, Korea Division of Rheumatology, Chung-Ang University Hospital, Seoul, Korea Division of Rheumatology, Hanyang University Guri Hospital, Guri, Korea Division of Rheumatology, Inje University Haeundae Paik Hospital, Busan, Korea Division of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, KoreaBackground/Aims The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods This was a nationwide multicenter observational study. Patients who had three or more active joint counts and abnormal inf lammatory marker in blood test were enrolled. The selection of DMARDs was determined by the attending rheumatologist. Clinical parameters, laboratory findings, and Health Assessment Questionnaire (HAQ) scores were obtained at baseline and at 6 and 12 months. Serial SDAI changes and clinical remission rate at 6 and 12 months were assessed. Results A total of 850 patients participated in this study. The mean baseline SDAI score in bDMARD group was higher than that in cDMARD group (32.08 ± 12.98 vs 25.69 ± 10.97, p < 0.0001). Mean change of SDAI at 12 months was –19.0 in the bDMARD group and –12.6 in the cDMARD group (p < 0.0001). Clinical remission rates at 12 months in bDMARD and cDMARD groups were 15.4% and 14.6%, respectively. Patient global assessment and HAQ at 12 months were also significantly improved in both groups. Multivariate logistic regression showed that baseline HAQ score was the most notable factor associated with remission. Conclusions There was a significant reduction in SDAI within 12 months after receiving DMARDs in Korean seropositive RA patients irrespective of bDMARD or cDMARD use in real-world practice. Clinical remission was achieved in those with lower baseline HAQ scores.http://www.kjim.org/upload/pdf/kjim-2018-137.pdfarthritis, rheumatoidantirheumatic agentsbiological therapy |
| spellingShingle | Kichul Shin Sung Soo Kim Sang-Heon Lee Seung-Jae Hong Sung Jae Choi Jung-Yoon Choe Seung-Geun Lee Hoon-Suk Cha Eun Young Lee Sung-Hwan Park Jin-Wuk Hur Sung Soo Na Chang-Hee Suh Min Wook So Seung Won Choi Dong-Hyuk Sheen Won Park Shin-Seok Lee Wan Hee Ryu Jin Seok Kim Jung Soo Song Hye Soon Lee Seong Ho Kim Dae-Hyun Yoo Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity The Korean Journal of Internal Medicine arthritis, rheumatoid antirheumatic agents biological therapy |
| title | Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity |
| title_full | Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity |
| title_fullStr | Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity |
| title_full_unstemmed | Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity |
| title_short | Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity |
| title_sort | simplified disease activity changes in real world practice a nationwide observational study of seropositive rheumatoid arthritis patients with moderate to high disease activity |
| topic | arthritis, rheumatoid antirheumatic agents biological therapy |
| url | http://www.kjim.org/upload/pdf/kjim-2018-137.pdf |
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