Upregulation of the Vitamin D Receptor in the Nasal Mucosa of Patients With Allergic Rhinitis
Background and Objectives Vitamin D modulates immunity, including that of allergic diseases, and plays its roles through contact with vitamin D receptors (VDR). Recent studies have shown that patients with allergic rhinitis have low systemic serum vitamin D level. However, the expression of VDR in l...
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| Format: | Article |
| Language: | English |
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Korean Rhinologic Society
2021-11-01
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| Series: | Journal of Rhinology |
| Subjects: | |
| Online Access: | http://www.j-rhinology.org/upload/pdf/jr-2021-00364.pdf |
| _version_ | 1818461451128406016 |
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| author | Hyeon Geun Kim Da Bin Lee Tae Hoon Lee Bo Yoon Choi Mun Soo Han Sang Hag Lee Tae Hoon Kim |
| author_facet | Hyeon Geun Kim Da Bin Lee Tae Hoon Lee Bo Yoon Choi Mun Soo Han Sang Hag Lee Tae Hoon Kim |
| author_sort | Hyeon Geun Kim |
| collection | DOAJ |
| description | Background and Objectives Vitamin D modulates immunity, including that of allergic diseases, and plays its roles through contact with vitamin D receptors (VDR). Recent studies have shown that patients with allergic rhinitis have low systemic serum vitamin D level. However, the expression of VDR in local tissue such as human nasal mucosa has not been investigated. Our study demonstrated that, in nasal mucosa of normal controls and patients with allergic rhinitis. Materials and Methods Nasal mucosa were harvested from twenty-five patients who had normal nasal mucosa and twenty-five patients with allergic rhinitis. After the total RNA isolation, we performed reverse transcriptase-polymerase chain reaction, immunohistochemical staining and western blot analysis. Results VDR were expressed in submucosal glands and the superficial layer of epithelial cell, and that inflammatory cells are expressed more highly in the nasal mucosa of patients with allergic rhinitis compared to those without. In the mucosa of patients with allergic rhinitis, VDR expression level was upregulated compared to that in normal nasal mucosa. Conclusion This findings suggest that VDR plays a role in the pathogenesis of allergic rhinitis. Additional research is needed to determine the mechanism and consequences of VDR upregulation. |
| first_indexed | 2024-12-14T23:46:21Z |
| format | Article |
| id | doaj.art-726082fb230c482384b86ba70fd09d5c |
| institution | Directory Open Access Journal |
| issn | 2384-4361 |
| language | English |
| last_indexed | 2024-12-14T23:46:21Z |
| publishDate | 2021-11-01 |
| publisher | Korean Rhinologic Society |
| record_format | Article |
| series | Journal of Rhinology |
| spelling | doaj.art-726082fb230c482384b86ba70fd09d5c2022-12-21T22:43:22ZengKorean Rhinologic SocietyJournal of Rhinology2384-43612021-11-0128314114610.18787/jr.2021.00364728Upregulation of the Vitamin D Receptor in the Nasal Mucosa of Patients With Allergic RhinitisHyeon Geun Kim0Da Bin Lee1Tae Hoon Lee2Bo Yoon Choi3Mun Soo Han4Sang Hag Lee5Tae Hoon Kim6 Department of Otorhinolaryngology-Head & Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea Department of Otorhinolaryngology-Head & Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea Department of Otorhinolaryngology-Head & Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea Department of Otorhinolaryngology-Head & Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea Department of Otorhinolaryngology-Head & Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea Department of Otorhinolaryngology-Head & Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea Department of Otorhinolaryngology-Head & Neck Surgery, Korea University College of Medicine, Seoul, Republic of KoreaBackground and Objectives Vitamin D modulates immunity, including that of allergic diseases, and plays its roles through contact with vitamin D receptors (VDR). Recent studies have shown that patients with allergic rhinitis have low systemic serum vitamin D level. However, the expression of VDR in local tissue such as human nasal mucosa has not been investigated. Our study demonstrated that, in nasal mucosa of normal controls and patients with allergic rhinitis. Materials and Methods Nasal mucosa were harvested from twenty-five patients who had normal nasal mucosa and twenty-five patients with allergic rhinitis. After the total RNA isolation, we performed reverse transcriptase-polymerase chain reaction, immunohistochemical staining and western blot analysis. Results VDR were expressed in submucosal glands and the superficial layer of epithelial cell, and that inflammatory cells are expressed more highly in the nasal mucosa of patients with allergic rhinitis compared to those without. In the mucosa of patients with allergic rhinitis, VDR expression level was upregulated compared to that in normal nasal mucosa. Conclusion This findings suggest that VDR plays a role in the pathogenesis of allergic rhinitis. Additional research is needed to determine the mechanism and consequences of VDR upregulation.http://www.j-rhinology.org/upload/pdf/jr-2021-00364.pdfvitamin dvitamin d receptorvdrallergic rhinitisnasal mucosa |
| spellingShingle | Hyeon Geun Kim Da Bin Lee Tae Hoon Lee Bo Yoon Choi Mun Soo Han Sang Hag Lee Tae Hoon Kim Upregulation of the Vitamin D Receptor in the Nasal Mucosa of Patients With Allergic Rhinitis Journal of Rhinology vitamin d vitamin d receptor vdr allergic rhinitis nasal mucosa |
| title | Upregulation of the Vitamin D Receptor in the Nasal Mucosa of Patients With Allergic Rhinitis |
| title_full | Upregulation of the Vitamin D Receptor in the Nasal Mucosa of Patients With Allergic Rhinitis |
| title_fullStr | Upregulation of the Vitamin D Receptor in the Nasal Mucosa of Patients With Allergic Rhinitis |
| title_full_unstemmed | Upregulation of the Vitamin D Receptor in the Nasal Mucosa of Patients With Allergic Rhinitis |
| title_short | Upregulation of the Vitamin D Receptor in the Nasal Mucosa of Patients With Allergic Rhinitis |
| title_sort | upregulation of the vitamin d receptor in the nasal mucosa of patients with allergic rhinitis |
| topic | vitamin d vitamin d receptor vdr allergic rhinitis nasal mucosa |
| url | http://www.j-rhinology.org/upload/pdf/jr-2021-00364.pdf |
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