Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the <i>Cannabis sativa</i> L. cv. <i>strawberry</i>
<i>Cannabis sativa</i> products have historically been used for healing purposes; now their biological properties are supported with scientific evidence, but modern research has not yet fully developed its therapeutic potential. This study focuses on the cultivar of <i>C. sativa<...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/2/219 |
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| author | Laura Serventi Giancarlo Angeles Flores Gaia Cusumano Davide Barbaro Bruno Tirillini Roberto Venanzoni Paola Angelini Alessandra Acquaviva Simonetta Cristina Di Simone Giustino Orlando Gokhan Zengin Luigi Menghini Claudio Ferrante |
| author_facet | Laura Serventi Giancarlo Angeles Flores Gaia Cusumano Davide Barbaro Bruno Tirillini Roberto Venanzoni Paola Angelini Alessandra Acquaviva Simonetta Cristina Di Simone Giustino Orlando Gokhan Zengin Luigi Menghini Claudio Ferrante |
| author_sort | Laura Serventi |
| collection | DOAJ |
| description | <i>Cannabis sativa</i> products have historically been used for healing purposes; now their biological properties are supported with scientific evidence, but modern research has not yet fully developed its therapeutic potential. This study focuses on the cultivar of <i>C. sativa</i> called strawberry to understand the biological and medical potentials of hydroalcoholic extracts from two different parts of the plant: leaves and inflorescences. Two biological assets were investigated including antioxidant and antimicrobial potential. Additionally, quantitative determination of phenolic and terpenophenol compounds was conducted. The antimicrobial action was highlighted for the hydroalcoholic extract from inflorescences, especially against <i>Escherichia coli</i> and <i>Bacillus subtilis.</i> Among the dermatophytes’ strains, the most sensitive was <i>Arthroderma currey</i>. These effects could be related albeit partially to the pattern of the phenolics detected, among which the most prominent one was benzoic acid. On the other hand, antioxidant and antimicrobial effects of the extracts could be also mediated by the main terpenophenolics identified and quantified, namely cannabidiolic acid and cannabidiol. Collectively, the present data point to the potential use of the inflorescences from the <i>C. sativa</i> cultivar strawberry as a valuable plant material for the development of bioactive extracts with antioxidant and antimicrobial effects |
| first_indexed | 2024-03-11T09:15:05Z |
| format | Article |
| id | doaj.art-72614c2f253041f0aceb5932b59ba9df |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T09:15:05Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-72614c2f253041f0aceb5932b59ba9df2023-11-16T18:45:01ZengMDPI AGAntioxidants2076-39212023-01-0112221910.3390/antiox12020219Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the <i>Cannabis sativa</i> L. cv. <i>strawberry</i>Laura Serventi0Giancarlo Angeles Flores1Gaia Cusumano2Davide Barbaro3Bruno Tirillini4Roberto Venanzoni5Paola Angelini6Alessandra Acquaviva7Simonetta Cristina Di Simone8Giustino Orlando9Gokhan Zengin10Luigi Menghini11Claudio Ferrante12Department of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, ItalyDepartment of Biomolecular Sciences, University of Urbino, 61029 Urbino, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, ItalyBotanic Garden “Giardino dei Semplici”, Department of Pharmacy, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, ItalyBotanic Garden “Giardino dei Semplici”, Department of Pharmacy, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, ItalyBotanic Garden “Giardino dei Semplici”, Department of Pharmacy, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, ItalyPhysiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, 42130 Konya, TurkeyBotanic Garden “Giardino dei Semplici”, Department of Pharmacy, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, ItalyBotanic Garden “Giardino dei Semplici”, Department of Pharmacy, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, Italy<i>Cannabis sativa</i> products have historically been used for healing purposes; now their biological properties are supported with scientific evidence, but modern research has not yet fully developed its therapeutic potential. This study focuses on the cultivar of <i>C. sativa</i> called strawberry to understand the biological and medical potentials of hydroalcoholic extracts from two different parts of the plant: leaves and inflorescences. Two biological assets were investigated including antioxidant and antimicrobial potential. Additionally, quantitative determination of phenolic and terpenophenol compounds was conducted. The antimicrobial action was highlighted for the hydroalcoholic extract from inflorescences, especially against <i>Escherichia coli</i> and <i>Bacillus subtilis.</i> Among the dermatophytes’ strains, the most sensitive was <i>Arthroderma currey</i>. These effects could be related albeit partially to the pattern of the phenolics detected, among which the most prominent one was benzoic acid. On the other hand, antioxidant and antimicrobial effects of the extracts could be also mediated by the main terpenophenolics identified and quantified, namely cannabidiolic acid and cannabidiol. Collectively, the present data point to the potential use of the inflorescences from the <i>C. sativa</i> cultivar strawberry as a valuable plant material for the development of bioactive extracts with antioxidant and antimicrobial effectshttps://www.mdpi.com/2076-3921/12/2/219<i>Cannabis sativa</i>antimicrobialantioxidantphenolic compoundsbenzoic acidcannabidiol |
| spellingShingle | Laura Serventi Giancarlo Angeles Flores Gaia Cusumano Davide Barbaro Bruno Tirillini Roberto Venanzoni Paola Angelini Alessandra Acquaviva Simonetta Cristina Di Simone Giustino Orlando Gokhan Zengin Luigi Menghini Claudio Ferrante Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the <i>Cannabis sativa</i> L. cv. <i>strawberry</i> Antioxidants <i>Cannabis sativa</i> antimicrobial antioxidant phenolic compounds benzoic acid cannabidiol |
| title | Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the <i>Cannabis sativa</i> L. cv. <i>strawberry</i> |
| title_full | Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the <i>Cannabis sativa</i> L. cv. <i>strawberry</i> |
| title_fullStr | Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the <i>Cannabis sativa</i> L. cv. <i>strawberry</i> |
| title_full_unstemmed | Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the <i>Cannabis sativa</i> L. cv. <i>strawberry</i> |
| title_short | Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the <i>Cannabis sativa</i> L. cv. <i>strawberry</i> |
| title_sort | comparative investigation of antimicrobial and antioxidant effects of the extracts from the inflorescences and leaves of the i cannabis sativa i l cv i strawberry i |
| topic | <i>Cannabis sativa</i> antimicrobial antioxidant phenolic compounds benzoic acid cannabidiol |
| url | https://www.mdpi.com/2076-3921/12/2/219 |
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