Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation
There has been a notable increase in rhino-orbito-cerebral mucormycosis (ROCM) post-coronavirus disease 2019 (COVID-19), which is an invasive fungal infection with a fatal outcome. Magnetic resonance imaging (MRI) is a valuable tool for early diagnosis of ROCM and assists in the proper management of...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/9/1546 |
| _version_ | 1827743133578821632 |
|---|---|
| author | Rania Mostafa Hassan Yassir Edrees Almalki Mohammad Abd Alkhalik Basha Mai Ahmed Gobran Saad Misfer Alqahtani Abdullah M. Assiri Saeed Alqahtani Sharifa Khalid Alduraibi Mervat Aboualkheir Ziyad A. Almushayti Asim S. Aldhilan Sameh Abdelaziz Aly Asmaa A. Alshamy |
| author_facet | Rania Mostafa Hassan Yassir Edrees Almalki Mohammad Abd Alkhalik Basha Mai Ahmed Gobran Saad Misfer Alqahtani Abdullah M. Assiri Saeed Alqahtani Sharifa Khalid Alduraibi Mervat Aboualkheir Ziyad A. Almushayti Asim S. Aldhilan Sameh Abdelaziz Aly Asmaa A. Alshamy |
| author_sort | Rania Mostafa Hassan |
| collection | DOAJ |
| description | There has been a notable increase in rhino-orbito-cerebral mucormycosis (ROCM) post-coronavirus disease 2019 (COVID-19), which is an invasive fungal infection with a fatal outcome. Magnetic resonance imaging (MRI) is a valuable tool for early diagnosis of ROCM and assists in the proper management of these cases. This study aimed to describe the characteristic MRI findings of ROCM in post-COVID-19 patients to help in the early diagnosis and management of these patients. This retrospective descriptive study was conducted at a single hospital and included 52 patients with COVID-19 and a histopathologically proven ROCM infection who were referred for an MRI of the paranasal sinuses (PNS) due to sino-orbital manifestations. Two radiologists reviewed all the MR images in consensus. The diagnosis was confirmed by histopathological examination. The maxillary sinus was the most commonly affected PNS (96.2%). In most patients (57.7%), multiple sinuses were involved with the black turbinate sign on postcontrast images. Extrasinus was evident in 43 patients with orbital involvement. The pterygopalatine fossa was involved in four patients. Three patients had cavernous sinus extension, two had pachymeningeal enhancement, and one had epidural collection. The alveolar margin was affected in two patients, and five patients had an extension to the cheek. The awareness of radiologists by the characteristic MRI features of ROCM in post-COVID-19 patients helps in early detection, early proper management, and prevention of morbid complications. |
| first_indexed | 2024-03-11T04:21:11Z |
| format | Article |
| id | doaj.art-726198e360e34042bd475c1b27aea95e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T04:21:11Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-726198e360e34042bd475c1b27aea95e2023-11-17T22:45:08ZengMDPI AGDiagnostics2075-44182023-04-01139154610.3390/diagnostics13091546Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological CorrelationRania Mostafa Hassan0Yassir Edrees Almalki1Mohammad Abd Alkhalik Basha2Mai Ahmed Gobran3Saad Misfer Alqahtani4Abdullah M. Assiri5Saeed Alqahtani6Sharifa Khalid Alduraibi7Mervat Aboualkheir8Ziyad A. Almushayti9Asim S. Aldhilan10Sameh Abdelaziz Aly11Asmaa A. Alshamy12Department of Diagnostic Radiology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, EgyptDivision of Radiology, Department of Internal Medicine, Medical College, Najran University, Najran 61441, Saudi ArabiaDepartment of Diagnostic Radiology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Surgical Pathology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Pathology, College of Medicine, Najran University Hospital, Najran University, Najran 61441, Saudi ArabiaDepartment of Surgery, College of Medicine, Najran University, Najran 61441, Saudi ArabiaDepartment of Surgery, College of Medicine, Najran University, Najran 61441, Saudi ArabiaDepartment of Radiology, College of Medicine, Qassim University, Buraidah 52571, Saudi ArabiaDepartment of Radiology and Medical Imaging, College of Medicine, Taibah University, Madinah 42353, Saudi ArabiaDepartment of Radiology, College of Medicine, Qassim University, Buraidah 52571, Saudi ArabiaDepartment of Radiology, College of Medicine, Qassim University, Buraidah 52571, Saudi ArabiaDepartment of Diagnostic Radiology, Faculty of Human Medicine, Benha University, Benha 13511, EgyptDepartment of Diagnostic Radiology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, EgyptThere has been a notable increase in rhino-orbito-cerebral mucormycosis (ROCM) post-coronavirus disease 2019 (COVID-19), which is an invasive fungal infection with a fatal outcome. Magnetic resonance imaging (MRI) is a valuable tool for early diagnosis of ROCM and assists in the proper management of these cases. This study aimed to describe the characteristic MRI findings of ROCM in post-COVID-19 patients to help in the early diagnosis and management of these patients. This retrospective descriptive study was conducted at a single hospital and included 52 patients with COVID-19 and a histopathologically proven ROCM infection who were referred for an MRI of the paranasal sinuses (PNS) due to sino-orbital manifestations. Two radiologists reviewed all the MR images in consensus. The diagnosis was confirmed by histopathological examination. The maxillary sinus was the most commonly affected PNS (96.2%). In most patients (57.7%), multiple sinuses were involved with the black turbinate sign on postcontrast images. Extrasinus was evident in 43 patients with orbital involvement. The pterygopalatine fossa was involved in four patients. Three patients had cavernous sinus extension, two had pachymeningeal enhancement, and one had epidural collection. The alveolar margin was affected in two patients, and five patients had an extension to the cheek. The awareness of radiologists by the characteristic MRI features of ROCM in post-COVID-19 patients helps in early detection, early proper management, and prevention of morbid complications.https://www.mdpi.com/2075-4418/13/9/1546MRImucormycosissinusorbitCOVID-19 |
| spellingShingle | Rania Mostafa Hassan Yassir Edrees Almalki Mohammad Abd Alkhalik Basha Mai Ahmed Gobran Saad Misfer Alqahtani Abdullah M. Assiri Saeed Alqahtani Sharifa Khalid Alduraibi Mervat Aboualkheir Ziyad A. Almushayti Asim S. Aldhilan Sameh Abdelaziz Aly Asmaa A. Alshamy Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation Diagnostics MRI mucormycosis sinus orbit COVID-19 |
| title | Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation |
| title_full | Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation |
| title_fullStr | Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation |
| title_full_unstemmed | Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation |
| title_short | Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation |
| title_sort | magnetic resonance imaging features of rhino orbito cerebral mucormycosis in post covid 19 patients radio pathological correlation |
| topic | MRI mucormycosis sinus orbit COVID-19 |
| url | https://www.mdpi.com/2075-4418/13/9/1546 |
| work_keys_str_mv | AT raniamostafahassan magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT yassiredreesalmalki magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT mohammadabdalkhalikbasha magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT maiahmedgobran magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT saadmisferalqahtani magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT abdullahmassiri magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT saeedalqahtani magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT sharifakhalidalduraibi magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT mervataboualkheir magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT ziyadaalmushayti magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT asimsaldhilan magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT samehabdelazizaly magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation AT asmaaaalshamy magneticresonanceimagingfeaturesofrhinoorbitocerebralmucormycosisinpostcovid19patientsradiopathologicalcorrelation |