Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients
Abstract Objective: To evaluate hypothalamic-pi- tuitary-gonadal (HPG) axis alterations at 1 and 12 months after kidney transplan- tation (KT) and their association with in- sulin resistance. Methods: A retrospective clinical study was conducted in a tertiary care center in kidney transplantation...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2022-05-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005028401&lng=en&tlng=en |
| _version_ | 1818006343502528512 |
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| author | Lourdes Balcázar-Hernández Victoria Mendoza-Zubieta Baldomero González-Virla Brenda González-García Mariana Osorio-Olvera Jesús Ubaldo Peñaloza-Juarez Irene Irisson-Mora Martha Cruz-López Raúl Rodríguez-Gómez Ramón Espinoza-Pérez Guadalupe Vargas-Ortega |
| author_facet | Lourdes Balcázar-Hernández Victoria Mendoza-Zubieta Baldomero González-Virla Brenda González-García Mariana Osorio-Olvera Jesús Ubaldo Peñaloza-Juarez Irene Irisson-Mora Martha Cruz-López Raúl Rodríguez-Gómez Ramón Espinoza-Pérez Guadalupe Vargas-Ortega |
| author_sort | Lourdes Balcázar-Hernández |
| collection | DOAJ |
| description | Abstract Objective: To evaluate hypothalamic-pi- tuitary-gonadal (HPG) axis alterations at 1 and 12 months after kidney transplan- tation (KT) and their association with in- sulin resistance. Methods: A retrospective clinical study was conducted in a tertiary care center in kidney transplantation recipients (KTRs) aged 18- 50 years with primary kidney disease and stable renal graft function. LH, FSH, E2/T, and HOMA-IR were assessed at 1 and 12 months after KT. Results: Twenty-five KTRs were included; 53% were men, and the mean age was 30.6±7.7 years. BMI was 22.3 (20.4-24.6) kg/m2, and 36% had hypogonadism at 1 month vs 8% at 12 months (p=0.001). Re- mission of hypogonadism was observed in all men, while in women, hypogonadotropic hypogonadism persisted in two KTRs at 12 months. A positive correlation between go- nadotrophins and age at 1 and 12 months was evident. Fifty-six percent of patients had insulin resistance (IR) at 1 month and 36% at 12 months (p=0.256). HOMA-IR showed a negative correlation with E2 (r=- 0.60; p=0.050) and T (r=-0.709; p=0.049) at 1 month, with no correlation at 12 months. HOMA-IR at 12 months after KT correlated positively with BMI (r=0.52; p=0.011) and tacrolimus dose (r=0.53; p=0.016). Conclusion: Successful KT restores the HPG axis in the first year. Hypogonadism had a negative correlation with IR in the early pe- riod after KT, but it was not significant at 12 months. |
| first_indexed | 2024-04-14T04:59:43Z |
| format | Article |
| id | doaj.art-7265fd0a6ff5495688a6bdd89b569cd6 |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-04-14T04:59:43Z |
| publishDate | 2022-05-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-7265fd0a6ff5495688a6bdd89b569cd62022-12-22T02:11:00ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392022-05-0110.1590/2175-8239-jbn-2021-0250enHypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipientsLourdes Balcázar-Hernándezhttps://orcid.org/0000-0002-0373-6641Victoria Mendoza-Zubietahttps://orcid.org/0000-0002-5394-9856Baldomero González-Virlahttps://orcid.org/0000-0001-6924-2209Brenda González-Garcíahttps://orcid.org/0000-0001-8911-9320Mariana Osorio-Olverahttps://orcid.org/0000-0003-4127-7308Jesús Ubaldo Peñaloza-Juarezhttps://orcid.org/0000-0001-7573-2220Irene Irisson-Morahttps://orcid.org/0000-0001-9523-4624Martha Cruz-Lópezhttps://orcid.org/0000-0002-0051-4381Raúl Rodríguez-Gómezhttps://orcid.org/0000-0001-7773-721XRamón Espinoza-Pérezhttps://orcid.org/0000-0002-1807-736XGuadalupe Vargas-Ortegahttps://orcid.org/0000-0002-2225-2925Abstract Objective: To evaluate hypothalamic-pi- tuitary-gonadal (HPG) axis alterations at 1 and 12 months after kidney transplan- tation (KT) and their association with in- sulin resistance. Methods: A retrospective clinical study was conducted in a tertiary care center in kidney transplantation recipients (KTRs) aged 18- 50 years with primary kidney disease and stable renal graft function. LH, FSH, E2/T, and HOMA-IR were assessed at 1 and 12 months after KT. Results: Twenty-five KTRs were included; 53% were men, and the mean age was 30.6±7.7 years. BMI was 22.3 (20.4-24.6) kg/m2, and 36% had hypogonadism at 1 month vs 8% at 12 months (p=0.001). Re- mission of hypogonadism was observed in all men, while in women, hypogonadotropic hypogonadism persisted in two KTRs at 12 months. A positive correlation between go- nadotrophins and age at 1 and 12 months was evident. Fifty-six percent of patients had insulin resistance (IR) at 1 month and 36% at 12 months (p=0.256). HOMA-IR showed a negative correlation with E2 (r=- 0.60; p=0.050) and T (r=-0.709; p=0.049) at 1 month, with no correlation at 12 months. HOMA-IR at 12 months after KT correlated positively with BMI (r=0.52; p=0.011) and tacrolimus dose (r=0.53; p=0.016). Conclusion: Successful KT restores the HPG axis in the first year. Hypogonadism had a negative correlation with IR in the early pe- riod after KT, but it was not significant at 12 months.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005028401&lng=en&tlng=enKidney TransplantationHy- pogonadismEstradiolTestosteroneGo- nadotropinsHyperinsulinism |
| spellingShingle | Lourdes Balcázar-Hernández Victoria Mendoza-Zubieta Baldomero González-Virla Brenda González-García Mariana Osorio-Olvera Jesús Ubaldo Peñaloza-Juarez Irene Irisson-Mora Martha Cruz-López Raúl Rodríguez-Gómez Ramón Espinoza-Pérez Guadalupe Vargas-Ortega Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients Brazilian Journal of Nephrology Kidney Transplantation Hy- pogonadism Estradiol Testosterone Go- nadotropins Hyperinsulinism |
| title | Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
| title_full | Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
| title_fullStr | Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
| title_full_unstemmed | Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
| title_short | Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
| title_sort | hypothalamic pituitary gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
| topic | Kidney Transplantation Hy- pogonadism Estradiol Testosterone Go- nadotropins Hyperinsulinism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005028401&lng=en&tlng=en |
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