Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).

Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).

Tuberous sclerosis complex (TSC) is a human genetic disorder in which loss of either TSC1 or TSC2 leads to development of hamartoma lesions, which can progress and be life-threatening or fatal. The TSC1/TSC2 protein complex regulates the state of activation of mTORC1. Tsc2(+/-) mice develop renal cy...

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Bibliographic Details
Main Authors:	Neil Auricchio, Izabela Malinowska, Reuben Shaw, Brendan D Manning, David J Kwiatkowski
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3283697?pdf=render

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