Acinar Cell Cystadenocarcinoma of the Pancreas
Acinar cell cystadenocarcinoma is a rare malignant epithelial neoplasm of the pancreas with a diffusely cystic, gross architecture in which the cysts are lined with neoplastic epithelial cells that demonstrate evidence of pancreatic exocrine enzyme production. This is the 10th case that has been rep...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-09-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/455185 |
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| author | Keita Aoto Tatsuo Shimura Yasuhide Kofunato Ryo Okada Rei Yashima Yuichiro Kiko Seiichi Takenoshita |
| author_facet | Keita Aoto Tatsuo Shimura Yasuhide Kofunato Ryo Okada Rei Yashima Yuichiro Kiko Seiichi Takenoshita |
| author_sort | Keita Aoto |
| collection | DOAJ |
| description | Acinar cell cystadenocarcinoma is a rare malignant epithelial neoplasm of the pancreas with a diffusely cystic, gross architecture in which the cysts are lined with neoplastic epithelial cells that demonstrate evidence of pancreatic exocrine enzyme production. This is the 10th case that has been reported in the literature. A 77-year-old male complaining of left hypochondrial pain was referred to our hospital for treatment of a pancreatic tumor. A huge, honeycomb-structured tumor was detected in the pancreatic tail. Distal pancreatectomy with total resection of the residual stomach and partial resection of the transverse colon were performed. Microscopically, there were variably sized cystic lesions in the tumor. Immunohistochemical examinations revealed that tumor cells were positive for alpha 1-antichymotrypsin and alpha 1-trypsin, showing that tumor cells had features of pancreatic acinar cells. Thus, the tumor was diagnosed as acinar cell cystadenocarcinoma. Herein, we report a rare case with acinar cell cystadenocarcinoma, which is the 10th case reported in the literature based on a PubMed search. We managed to resect the tumor completely by distal pancreatectomy with total resection of the residual stomach and partial resection of the transverse colon. The patient is still alive 26 months after surgery without any recurrence after 1 year of adjuvant chemotherapy with S-1. |
| first_indexed | 2024-12-12T16:43:29Z |
| format | Article |
| id | doaj.art-7268df60fad343cbb307581c0b235434 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-12T16:43:29Z |
| publishDate | 2017-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-7268df60fad343cbb307581c0b2354342022-12-22T00:18:31ZengKarger PublishersCase Reports in Gastroenterology1662-06312017-09-0111250451010.1159/000455185455185Acinar Cell Cystadenocarcinoma of the PancreasKeita AotoTatsuo ShimuraYasuhide KofunatoRyo OkadaRei YashimaYuichiro KikoSeiichi TakenoshitaAcinar cell cystadenocarcinoma is a rare malignant epithelial neoplasm of the pancreas with a diffusely cystic, gross architecture in which the cysts are lined with neoplastic epithelial cells that demonstrate evidence of pancreatic exocrine enzyme production. This is the 10th case that has been reported in the literature. A 77-year-old male complaining of left hypochondrial pain was referred to our hospital for treatment of a pancreatic tumor. A huge, honeycomb-structured tumor was detected in the pancreatic tail. Distal pancreatectomy with total resection of the residual stomach and partial resection of the transverse colon were performed. Microscopically, there were variably sized cystic lesions in the tumor. Immunohistochemical examinations revealed that tumor cells were positive for alpha 1-antichymotrypsin and alpha 1-trypsin, showing that tumor cells had features of pancreatic acinar cells. Thus, the tumor was diagnosed as acinar cell cystadenocarcinoma. Herein, we report a rare case with acinar cell cystadenocarcinoma, which is the 10th case reported in the literature based on a PubMed search. We managed to resect the tumor completely by distal pancreatectomy with total resection of the residual stomach and partial resection of the transverse colon. The patient is still alive 26 months after surgery without any recurrence after 1 year of adjuvant chemotherapy with S-1.http://www.karger.com/Article/FullText/455185Acinar cell cystadenocarcinomaPancreatic cancerAlpha 1-antichymotrypsinAlpha 1-trypsin |
| spellingShingle | Keita Aoto Tatsuo Shimura Yasuhide Kofunato Ryo Okada Rei Yashima Yuichiro Kiko Seiichi Takenoshita Acinar Cell Cystadenocarcinoma of the Pancreas Case Reports in Gastroenterology Acinar cell cystadenocarcinoma Pancreatic cancer Alpha 1-antichymotrypsin Alpha 1-trypsin |
| title | Acinar Cell Cystadenocarcinoma of the Pancreas |
| title_full | Acinar Cell Cystadenocarcinoma of the Pancreas |
| title_fullStr | Acinar Cell Cystadenocarcinoma of the Pancreas |
| title_full_unstemmed | Acinar Cell Cystadenocarcinoma of the Pancreas |
| title_short | Acinar Cell Cystadenocarcinoma of the Pancreas |
| title_sort | acinar cell cystadenocarcinoma of the pancreas |
| topic | Acinar cell cystadenocarcinoma Pancreatic cancer Alpha 1-antichymotrypsin Alpha 1-trypsin |
| url | http://www.karger.com/Article/FullText/455185 |
| work_keys_str_mv | AT keitaaoto acinarcellcystadenocarcinomaofthepancreas AT tatsuoshimura acinarcellcystadenocarcinomaofthepancreas AT yasuhidekofunato acinarcellcystadenocarcinomaofthepancreas AT ryookada acinarcellcystadenocarcinomaofthepancreas AT reiyashima acinarcellcystadenocarcinomaofthepancreas AT yuichirokiko acinarcellcystadenocarcinomaofthepancreas AT seiichitakenoshita acinarcellcystadenocarcinomaofthepancreas |