Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance Phase
Background: Vancomycin is a glycopeptide antibiotic that was extensively used for treatment of gram positive infections. Therapeutic drug monitoring (TDM) is recommended to optimize efficacy and safety of vancomycin. Data regarding TDM of vancomycin are scant in septic patients especially during aug...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2019-07-01
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| Series: | Archives of Anesthesia and Critical Care |
| Subjects: | |
| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/238 |
| _version_ | 1811281291289559040 |
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| author | Omid Arasteh Hossein Khalili Mohammad Taghi Beigmohammadi Alireza Abdollahi Amirhooshang Mohammadpour Mohammadreza Salehi |
| author_facet | Omid Arasteh Hossein Khalili Mohammad Taghi Beigmohammadi Alireza Abdollahi Amirhooshang Mohammadpour Mohammadreza Salehi |
| author_sort | Omid Arasteh |
| collection | DOAJ |
| description | Background: Vancomycin is a glycopeptide antibiotic that was extensively used for treatment of gram positive infections. Therapeutic drug monitoring (TDM) is recommended to optimize efficacy and safety of vancomycin. Data regarding TDM of vancomycin are scant in septic patients especially during augmented renal clearance (ARC) phase.
Methods: In this observational study, 39 patients with diagnosis of sepsis that were in ARC phase were evaluated. The breakpoint for serum trough level of vancomycin was considered as 15 mg/l. The patients were stratified in two groups based on the measured serum trough levels (< 15 mg/l versus ≥15 mg/l).
Results: Clinical response and microbiological clearance were compared between the groups. In terms of clinical response, there was no significant difference between the groups (P = 0.677). Also, the microbiological clearance was not different between the groups (P= 1.00).
Conclusion: Septic patients during ARC phase had comparable clinical and microbial responses regardless of serum trough levels of vancomycin. |
| first_indexed | 2024-04-13T01:30:53Z |
| format | Article |
| id | doaj.art-72694982f3954c98a6117d5806065774 |
| institution | Directory Open Access Journal |
| issn | 2423-5849 |
| language | English |
| last_indexed | 2024-04-13T01:30:53Z |
| publishDate | 2019-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj.art-72694982f3954c98a6117d58060657742022-12-22T03:08:31ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492019-07-015310.18502/aacc.v5i3.1203Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance PhaseOmid Arasteh0Hossein Khalili1Mohammad Taghi Beigmohammadi2Alireza Abdollahi3Amirhooshang Mohammadpour4Mohammadreza Salehi5Department of Clinical Pharmacy, School of pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Clinical Pharmacy, School of pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Anesthesiology and Critical Care, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Clinical Pharmacy, School of pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Background: Vancomycin is a glycopeptide antibiotic that was extensively used for treatment of gram positive infections. Therapeutic drug monitoring (TDM) is recommended to optimize efficacy and safety of vancomycin. Data regarding TDM of vancomycin are scant in septic patients especially during augmented renal clearance (ARC) phase. Methods: In this observational study, 39 patients with diagnosis of sepsis that were in ARC phase were evaluated. The breakpoint for serum trough level of vancomycin was considered as 15 mg/l. The patients were stratified in two groups based on the measured serum trough levels (< 15 mg/l versus ≥15 mg/l). Results: Clinical response and microbiological clearance were compared between the groups. In terms of clinical response, there was no significant difference between the groups (P = 0.677). Also, the microbiological clearance was not different between the groups (P= 1.00). Conclusion: Septic patients during ARC phase had comparable clinical and microbial responses regardless of serum trough levels of vancomycin.https://aacc.tums.ac.ir/index.php/aacc/article/view/238VancomycinClinical responseMicrobiological clearanceSepsis |
| spellingShingle | Omid Arasteh Hossein Khalili Mohammad Taghi Beigmohammadi Alireza Abdollahi Amirhooshang Mohammadpour Mohammadreza Salehi Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance Phase Archives of Anesthesia and Critical Care Vancomycin Clinical response Microbiological clearance Sepsis |
| title | Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance Phase |
| title_full | Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance Phase |
| title_fullStr | Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance Phase |
| title_full_unstemmed | Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance Phase |
| title_short | Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance Phase |
| title_sort | correlation between serum vancomycin trough level and therapeutic response in septic patients during augmented renal clearance phase |
| topic | Vancomycin Clinical response Microbiological clearance Sepsis |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/238 |
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