Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain

Cerebrospinal fluid (CSF) is essential for brain development. Here, the authors use gold nanoparticle enhanced X-ray microtomography to map CSF distribution in post-natal rodents and describe particle size-dependent CSF pathways that transport CSF into the brain parenchyma of rodents.

Bibliographic Details
Main Authors: Shelei Pan, Peter H. Yang, Dakota DeFreitas, Sruthi Ramagiri, Peter O. Bayguinov, Carl D. Hacker, Abraham Z. Snyder, Jackson Wilborn, Hengbo Huang, Gretchen M. Koller, Dhvanii K. Raval, Grace L. Halupnik, Sanja Sviben, Samuel Achilefu, Rui Tang, Gabriel Haller, James D. Quirk, James A. J. Fitzpatrick, Prabagaran Esakky, Jennifer M. Strahle
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36083-1
Description
Summary:Cerebrospinal fluid (CSF) is essential for brain development. Here, the authors use gold nanoparticle enhanced X-ray microtomography to map CSF distribution in post-natal rodents and describe particle size-dependent CSF pathways that transport CSF into the brain parenchyma of rodents.
ISSN:2041-1723