Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts

Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts

Abstract The (pro)renin receptor (PRR) is a multifunctional integral membrane protein that serves as a component of the vacuolar H+-ATPase (V-ATPase) and also activates (pro)renin. We recently showed that full-length PRR, found as part of a V-ATPase sub-complex, is abundant in extracellular vesicles...

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Bibliographic Details
Main Authors: Jonathan B. Murray, Christy Mikhael, Guanghong Han, Lorraine Perciliano de Faria, Wellington J. Rody, L. Shannon Holliday
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88665-y

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