Diesel exhaust in miners study: how to understand the findings?
<p>Abstract</p> <p>The Diesel Exhaust in Miners Study (DEMS) is an outstanding epidemiological project on the association between occupational diesel exhaust exposures, measured as long-term respirable elemental carbon (REC) estimates, and lung cancer mortality in a large cohort of...
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | Journal of Occupational Medicine and Toxicology |
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| Online Access: | http://www.occup-med.com/content/7/1/10 |
| _version_ | 1798005269435777024 |
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| author | Morfeld Peter |
| author_facet | Morfeld Peter |
| author_sort | Morfeld Peter |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The Diesel Exhaust in Miners Study (DEMS) is an outstanding epidemiological project on the association between occupational diesel exhaust exposures, measured as long-term respirable elemental carbon (REC) estimates, and lung cancer mortality in a large cohort of US miners. Two articles published recently (Attfield et al. (J Natl Cancer Inst Epub, <abbrgrp><abbr bid="B1">2012</abbr></abbrgrp>), Silverman et al. (J Natl Cancer Inst Epub, <abbrgrp><abbr bid="B2">2012</abbr></abbrgrp>)) dsescribed the epidemiological findings. These papers are expected to have considerable impact on the evaluation of the carcinogenic potential of diesel exhaust and, furthermore, on occupational and environmental limit value discussions related to diesel motor emissions and particle exposures. DEMS found remarkable exposure-response relationships between REC exposure estimates and lung cancer mortality - conditional on a pronounced effect of surface vs. underground work on lung cancer risk. If this risk factor is ignored the estimated REC-lung cancer association is attenuated substantially. The authors relied on this risk factor in their main analyses. However, this factor “surface/underground work” remained unexplained. The factor lead the authors to introduce unusual cross-product terms of location and smoking in adjustment procedures and even caused the authors to hypothesize that high REC exposures are protective against lung cancer excess risks due to smoking. To understand the reliability of these conclusions, we should ask basic questions about the data collection process in DEMS: Did the mortality follow-up procedures suffer from errors like those that affected the NCI formaldehyde cohort study? Are the REC and/or smoking data reliable, and are these data collected/constructed in such a way that the procedures allow valid comparisons between surface and underground workers? Without clarifying the issues raised in this Commentary the Diesel Exhaust in Miners Study remains to be difficult to interpret.</p> |
| first_indexed | 2024-04-11T12:37:41Z |
| format | Article |
| id | doaj.art-726d85fdab9d4ad3948690c1a437a7e2 |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-11T12:37:41Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-726d85fdab9d4ad3948690c1a437a7e22022-12-22T04:23:35ZengBMCJournal of Occupational Medicine and Toxicology1745-66732012-06-01711010.1186/1745-6673-7-10Diesel exhaust in miners study: how to understand the findings?Morfeld Peter<p>Abstract</p> <p>The Diesel Exhaust in Miners Study (DEMS) is an outstanding epidemiological project on the association between occupational diesel exhaust exposures, measured as long-term respirable elemental carbon (REC) estimates, and lung cancer mortality in a large cohort of US miners. Two articles published recently (Attfield et al. (J Natl Cancer Inst Epub, <abbrgrp><abbr bid="B1">2012</abbr></abbrgrp>), Silverman et al. (J Natl Cancer Inst Epub, <abbrgrp><abbr bid="B2">2012</abbr></abbrgrp>)) dsescribed the epidemiological findings. These papers are expected to have considerable impact on the evaluation of the carcinogenic potential of diesel exhaust and, furthermore, on occupational and environmental limit value discussions related to diesel motor emissions and particle exposures. DEMS found remarkable exposure-response relationships between REC exposure estimates and lung cancer mortality - conditional on a pronounced effect of surface vs. underground work on lung cancer risk. If this risk factor is ignored the estimated REC-lung cancer association is attenuated substantially. The authors relied on this risk factor in their main analyses. However, this factor “surface/underground work” remained unexplained. The factor lead the authors to introduce unusual cross-product terms of location and smoking in adjustment procedures and even caused the authors to hypothesize that high REC exposures are protective against lung cancer excess risks due to smoking. To understand the reliability of these conclusions, we should ask basic questions about the data collection process in DEMS: Did the mortality follow-up procedures suffer from errors like those that affected the NCI formaldehyde cohort study? Are the REC and/or smoking data reliable, and are these data collected/constructed in such a way that the procedures allow valid comparisons between surface and underground workers? Without clarifying the issues raised in this Commentary the Diesel Exhaust in Miners Study remains to be difficult to interpret.</p>http://www.occup-med.com/content/7/1/10Diesel exhaust in miners studyEpidemiologyLung cancerRespirable elemental carbon |
| spellingShingle | Morfeld Peter Diesel exhaust in miners study: how to understand the findings? Journal of Occupational Medicine and Toxicology Diesel exhaust in miners study Epidemiology Lung cancer Respirable elemental carbon |
| title | Diesel exhaust in miners study: how to understand the findings? |
| title_full | Diesel exhaust in miners study: how to understand the findings? |
| title_fullStr | Diesel exhaust in miners study: how to understand the findings? |
| title_full_unstemmed | Diesel exhaust in miners study: how to understand the findings? |
| title_short | Diesel exhaust in miners study: how to understand the findings? |
| title_sort | diesel exhaust in miners study how to understand the findings |
| topic | Diesel exhaust in miners study Epidemiology Lung cancer Respirable elemental carbon |
| url | http://www.occup-med.com/content/7/1/10 |
| work_keys_str_mv | AT morfeldpeter dieselexhaustinminersstudyhowtounderstandthefindings |