Telomere-Centromere-Driven Genomic Instability Contributes to Karyotype Evolution in a Mouse Model of Melanoma

Telomere-Centromere-Driven Genomic Instability Contributes to Karyotype Evolution in a Mouse Model of Melanoma

Aneuploidy and chromosomal instability (CIN) are hallmarks of most solid tumors. These alterations may result from inaccurate chromosomal segregation during mitosis, which can occur through several mechanisms including defective telomere metabolism, centrosome amplification, dysfunctional centromere...

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Bibliographic Details
Main Authors:	Amanda Gonçalves dos Santos Silva, Herbert Alexander Graves, Amanda Guffei, Tatiana Iervolino Ricca, Renato Arruda Mortara, Miriam Galvonas Jasiulionis, Sabine Mai
Format:	Article
Language:	English
Published:	Elsevier 2010-01-01
Series:	Neoplasia: An International Journal for Oncology Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558610800806

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