Acute toxicity and anthelmintic efficacy of khimedol
The purpose of the research: to study acute toxicity and anthelmintic efficacy of khimedol, a new anthelmintic preparation. Materials and methods. Khimedol, anthelmintic preparation which was received by means of streamlined synthesis in the Institute Chemistry and Chemical Technology of National Ac...
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| Format: | Article |
| Language: | Russian |
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Federal Scientific Centre VIEV
2019-10-01
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| Series: | Российский паразитологический журнал |
| Subjects: | |
| Online Access: | https://vniigis.elpub.ru/jour/article/view/495 |
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| author | K. R. Toimbetova M. A. Arzybaev A. B. Shakirov A. M. Malabaeva N. . Shyityeva |
| author_facet | K. R. Toimbetova M. A. Arzybaev A. B. Shakirov A. M. Malabaeva N. . Shyityeva |
| author_sort | K. R. Toimbetova |
| collection | DOAJ |
| description | The purpose of the research: to study acute toxicity and anthelmintic efficacy of khimedol, a new anthelmintic preparation. Materials and methods. Khimedol, anthelmintic preparation which was received by means of streamlined synthesis in the Institute Chemistry and Chemical Technology of National Academy of Science of Kyrgyz Republic was the object of the research (KG patent No. 1954, 2017). Experiments on identification of acute toxicity of khimedol were carried on 36 clinically healthy white mice of both genders with body weight about 18-22 g by means of oral supplementation of medication in the form of 10 % hydrous solution in dose of 1,000, 1,500, 2,000, 2,500 and 3,000 mg/kg of body weight. Statistical manipulation of digital materials was carried by the probit analysis method. Testing of anthelmintic efficacy of the medication was performed by control-test method on 40 lambs, which were infested by moniezia spontaneously. Khimedol was individually given to the lambs by mouth (per os) in a form of hydrous solution as a single dose of 10, 20, 30 mg/kg of body weight. Control animals were not undergone deworming. Flotation method was used for coprological surveys. Results and discussion. Maximum tolerated dose of khimedol (LD 0) for the white mice was 1,000 mg/kg, LD 16 - 1420 mg/kg, median lethal dose (LD 50) - 2,110 (1,563÷2,845.5) mg/kg, LD 84 - 2,970 mg/kg, and absolutely lethal dose (LD 100) - 3,000 mg/kg. Therefore, khimedol is a medication with low toxic potential to animals. During the experiments on testing the anthelmintic effectiveness of khimedol on sheep with monieziasis it has been established that the preparation exhibits its anthelmintic efficacy in a dose of 10 mg/kg: among 10 lambs 8 were treated from worms, and the number of eggs in 1 g of feces was decreased by 83.43%. Administration of khimedol in a dose of 20 and 30 mg/kg leads to full recovery of an animal from monieziasis (100%). |
| first_indexed | 2024-03-08T21:42:06Z |
| format | Article |
| id | doaj.art-726def794b4b400ab24c245777d97d42 |
| institution | Directory Open Access Journal |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| last_indexed | 2024-04-25T02:06:10Z |
| publishDate | 2019-10-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj.art-726def794b4b400ab24c245777d97d422024-03-07T14:34:26ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432019-10-01122626710.31016/1998-8435-2018-12-2-62-67492Acute toxicity and anthelmintic efficacy of khimedolK. R. Toimbetova0M. A. Arzybaev1A. B. Shakirov2A. M. Malabaeva3N. . Shyityeva4Kyrgyz National Agrarian University named after K. I. SkryabinKyrgyz National Agrarian University named after K. I. SkryabinKyrgyz National Agrarian University named after K. I. SkryabinInstitute Chemistry and Chemical Technology of National Academy of Science of Kyrgyz RepublicInstitute Chemistry and Chemical Technology of National Academy of Science of Kyrgyz RepublicThe purpose of the research: to study acute toxicity and anthelmintic efficacy of khimedol, a new anthelmintic preparation. Materials and methods. Khimedol, anthelmintic preparation which was received by means of streamlined synthesis in the Institute Chemistry and Chemical Technology of National Academy of Science of Kyrgyz Republic was the object of the research (KG patent No. 1954, 2017). Experiments on identification of acute toxicity of khimedol were carried on 36 clinically healthy white mice of both genders with body weight about 18-22 g by means of oral supplementation of medication in the form of 10 % hydrous solution in dose of 1,000, 1,500, 2,000, 2,500 and 3,000 mg/kg of body weight. Statistical manipulation of digital materials was carried by the probit analysis method. Testing of anthelmintic efficacy of the medication was performed by control-test method on 40 lambs, which were infested by moniezia spontaneously. Khimedol was individually given to the lambs by mouth (per os) in a form of hydrous solution as a single dose of 10, 20, 30 mg/kg of body weight. Control animals were not undergone deworming. Flotation method was used for coprological surveys. Results and discussion. Maximum tolerated dose of khimedol (LD 0) for the white mice was 1,000 mg/kg, LD 16 - 1420 mg/kg, median lethal dose (LD 50) - 2,110 (1,563÷2,845.5) mg/kg, LD 84 - 2,970 mg/kg, and absolutely lethal dose (LD 100) - 3,000 mg/kg. Therefore, khimedol is a medication with low toxic potential to animals. During the experiments on testing the anthelmintic effectiveness of khimedol on sheep with monieziasis it has been established that the preparation exhibits its anthelmintic efficacy in a dose of 10 mg/kg: among 10 lambs 8 were treated from worms, and the number of eggs in 1 g of feces was decreased by 83.43%. Administration of khimedol in a dose of 20 and 30 mg/kg leads to full recovery of an animal from monieziasis (100%).https://vniigis.elpub.ru/jour/article/view/495антигельминтикострая токсичностьлетальная дозахимедолбелые мышиовцымониезиозгельминтозыэффективностьдегельминтизацияanthelminticacute toxicitylethal dosekhimedolwhite micesheepmonieziasishelminthiasesefficacydeworming |
| spellingShingle | K. R. Toimbetova M. A. Arzybaev A. B. Shakirov A. M. Malabaeva N. . Shyityeva Acute toxicity and anthelmintic efficacy of khimedol Российский паразитологический журнал антигельминтик острая токсичность летальная доза химедол белые мыши овцы мониезиоз гельминтозы эффективность дегельминтизация anthelmintic acute toxicity lethal dose khimedol white mice sheep monieziasis helminthiases efficacy deworming |
| title | Acute toxicity and anthelmintic efficacy of khimedol |
| title_full | Acute toxicity and anthelmintic efficacy of khimedol |
| title_fullStr | Acute toxicity and anthelmintic efficacy of khimedol |
| title_full_unstemmed | Acute toxicity and anthelmintic efficacy of khimedol |
| title_short | Acute toxicity and anthelmintic efficacy of khimedol |
| title_sort | acute toxicity and anthelmintic efficacy of khimedol |
| topic | антигельминтик острая токсичность летальная доза химедол белые мыши овцы мониезиоз гельминтозы эффективность дегельминтизация anthelmintic acute toxicity lethal dose khimedol white mice sheep monieziasis helminthiases efficacy deworming |
| url | https://vniigis.elpub.ru/jour/article/view/495 |
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