Curvature strains as a global orchestrator of morphogenesis
Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information...
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| Format: | Article |
| Language: | English |
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American Physical Society
2022-05-01
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| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.4.023171 |
| _version_ | 1827285465596690432 |
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| author | Julius B. Kirkegaard |
| author_facet | Julius B. Kirkegaard |
| author_sort | Julius B. Kirkegaard |
| collection | DOAJ |
| description | Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information is encoded only through a locally preferred curvature, but with cell dynamics which simultaneously ensures that these interactions globally achieve morphogenesis and correct cell-neighbor exchanges to avoid cell stretches. This is achieved by a cell-cell interaction potential that drives correct cell intercalation to reorganize the cell sheet dynamically during the deformation processes. We demonstrate morphogenesis of simple three-dimensional shapes and study the effects of fixed cell neighbor connectivity and noisy cell division. |
| first_indexed | 2024-04-24T10:15:12Z |
| format | Article |
| id | doaj.art-726ed5329c0744229075e8fa53c8417d |
| institution | Directory Open Access Journal |
| issn | 2643-1564 |
| language | English |
| last_indexed | 2024-04-24T10:15:12Z |
| publishDate | 2022-05-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review Research |
| spelling | doaj.art-726ed5329c0744229075e8fa53c8417d2024-04-12T17:21:23ZengAmerican Physical SocietyPhysical Review Research2643-15642022-05-014202317110.1103/PhysRevResearch.4.023171Curvature strains as a global orchestrator of morphogenesisJulius B. KirkegaardSuccessful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information is encoded only through a locally preferred curvature, but with cell dynamics which simultaneously ensures that these interactions globally achieve morphogenesis and correct cell-neighbor exchanges to avoid cell stretches. This is achieved by a cell-cell interaction potential that drives correct cell intercalation to reorganize the cell sheet dynamically during the deformation processes. We demonstrate morphogenesis of simple three-dimensional shapes and study the effects of fixed cell neighbor connectivity and noisy cell division.http://doi.org/10.1103/PhysRevResearch.4.023171 |
| spellingShingle | Julius B. Kirkegaard Curvature strains as a global orchestrator of morphogenesis Physical Review Research |
| title | Curvature strains as a global orchestrator of morphogenesis |
| title_full | Curvature strains as a global orchestrator of morphogenesis |
| title_fullStr | Curvature strains as a global orchestrator of morphogenesis |
| title_full_unstemmed | Curvature strains as a global orchestrator of morphogenesis |
| title_short | Curvature strains as a global orchestrator of morphogenesis |
| title_sort | curvature strains as a global orchestrator of morphogenesis |
| url | http://doi.org/10.1103/PhysRevResearch.4.023171 |
| work_keys_str_mv | AT juliusbkirkegaard curvaturestrainsasaglobalorchestratorofmorphogenesis |