The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer.

The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer.

WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved antihelmintic drug that inhibits WNT signaling, to test whether pharmacologic inhibition of WNT signaling can specifically target TICs of aggressive bre...

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Bibliographic Details
Main Authors: Wei Xu, Lara Lacerda, Bisrat G Debeb, Rachel L Atkinson, Travis N Solley, Li Li, Darren Orton, John S McMurray, Brian I Hang, Ethan Lee, Ann H Klopp, Naoto T Ueno, James M Reuben, Savitri Krishnamurthy, Wendy A Woodward
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3754994?pdf=render

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