A novel electrocardiographic index for the diagnosis of diastolic dysfunction.
<h4>Background</h4>Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patient...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223898/?tool=EBI |
| _version_ | 1818338008077697024 |
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| author | Mehdi Namdar Patric Biaggi Barbara Stähli Bernhard Bütler Rubén Casado-Arroyo Danilo Ricciardi Moisés Rodríguez-Mañero Jan Steffel David Hürlimann Christian Schmied Carlo de Asmundis Gian-Battista Chierchia Andrea Sarkozy Thomas F Lüscher Rolf Jenni Firat Duru Walter J Paulus Pedro Brugada |
| author_facet | Mehdi Namdar Patric Biaggi Barbara Stähli Bernhard Bütler Rubén Casado-Arroyo Danilo Ricciardi Moisés Rodríguez-Mañero Jan Steffel David Hürlimann Christian Schmied Carlo de Asmundis Gian-Battista Chierchia Andrea Sarkozy Thomas F Lüscher Rolf Jenni Firat Duru Walter J Paulus Pedro Brugada |
| author_sort | Mehdi Namdar |
| collection | DOAJ |
| description | <h4>Background</h4>Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD.<h4>Methods and results</h4>ECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422 ± 24 ms and 434 ± 32 ms vs. 409 ± 25ms, p<0.0005) and shorter Tend-P and Tend-Q intervals, reflecting the electrical and mechanical diastole (240 ± 78 ms and 276 ± 108 ms vs. 373 ± 110 ms, p<0.0001; 409 ± 85 ms and 447 ± 115 ms vs. 526 ± 119 ms, p<0.0001). The PQ-interval was significantly longer in the patient group (169 ± 28ms and 171 ± 38ms vs. 153 ± 22ms, p<0.005). After adjusting for possible confounders, a novel index (Tend-P/[PQxAge]) showed a high performance for the recognition of DD, stayed robust in the validation group (sensitivity 82%, specificity 93%, positive predictive value 93%, negative predictive value 82%, accuracy 88%) and proved a substantial added value when combined with the indexed left atrial volume (LAESVI, sensitivity 90%, specificity 92%, positive predictive value 95%, negative predictive value 86%, accuracy 91%).<h4>Conclusions</h4>A novel electrocardiographic index Tend-P/(PQxAge) demonstrates a high diagnostic accuracy for the diagnosis of DD and yields a substantial added value when combined with the LAESVI. |
| first_indexed | 2024-12-13T15:04:16Z |
| format | Article |
| id | doaj.art-727165ec93f445be86d570884cd4056f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T15:04:16Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-727165ec93f445be86d570884cd4056f2022-12-21T23:41:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7915210.1371/journal.pone.0079152A novel electrocardiographic index for the diagnosis of diastolic dysfunction.Mehdi NamdarPatric BiaggiBarbara StähliBernhard BütlerRubén Casado-ArroyoDanilo RicciardiMoisés Rodríguez-MañeroJan SteffelDavid HürlimannChristian SchmiedCarlo de AsmundisGian-Battista ChierchiaAndrea SarkozyThomas F LüscherRolf JenniFirat DuruWalter J PaulusPedro Brugada<h4>Background</h4>Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD.<h4>Methods and results</h4>ECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422 ± 24 ms and 434 ± 32 ms vs. 409 ± 25ms, p<0.0005) and shorter Tend-P and Tend-Q intervals, reflecting the electrical and mechanical diastole (240 ± 78 ms and 276 ± 108 ms vs. 373 ± 110 ms, p<0.0001; 409 ± 85 ms and 447 ± 115 ms vs. 526 ± 119 ms, p<0.0001). The PQ-interval was significantly longer in the patient group (169 ± 28ms and 171 ± 38ms vs. 153 ± 22ms, p<0.005). After adjusting for possible confounders, a novel index (Tend-P/[PQxAge]) showed a high performance for the recognition of DD, stayed robust in the validation group (sensitivity 82%, specificity 93%, positive predictive value 93%, negative predictive value 82%, accuracy 88%) and proved a substantial added value when combined with the indexed left atrial volume (LAESVI, sensitivity 90%, specificity 92%, positive predictive value 95%, negative predictive value 86%, accuracy 91%).<h4>Conclusions</h4>A novel electrocardiographic index Tend-P/(PQxAge) demonstrates a high diagnostic accuracy for the diagnosis of DD and yields a substantial added value when combined with the LAESVI.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223898/?tool=EBI |
| spellingShingle | Mehdi Namdar Patric Biaggi Barbara Stähli Bernhard Bütler Rubén Casado-Arroyo Danilo Ricciardi Moisés Rodríguez-Mañero Jan Steffel David Hürlimann Christian Schmied Carlo de Asmundis Gian-Battista Chierchia Andrea Sarkozy Thomas F Lüscher Rolf Jenni Firat Duru Walter J Paulus Pedro Brugada A novel electrocardiographic index for the diagnosis of diastolic dysfunction. PLoS ONE |
| title | A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_full | A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_fullStr | A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_full_unstemmed | A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_short | A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_sort | novel electrocardiographic index for the diagnosis of diastolic dysfunction |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223898/?tool=EBI |
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