Prognostic factors in traumatic brain injuries in emergency department
Background: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young adults. The Extended Glasgow Outcome Score (GOSE) has been introduced to assess the global outcome after brain injuries. Therefore, we aimed to evaluate the prognostic factors associated with GOSE. Materi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=83;epage=83;aulast=Behzadnia |
| _version_ | 1811177529891880960 |
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| author | Mohammad Javad Behzadnia Mousareza Anbarlouei Seyed Morteza Hosseini Amir Bahador Boroumand |
| author_facet | Mohammad Javad Behzadnia Mousareza Anbarlouei Seyed Morteza Hosseini Amir Bahador Boroumand |
| author_sort | Mohammad Javad Behzadnia |
| collection | DOAJ |
| description | Background: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young adults. The Extended Glasgow Outcome Score (GOSE) has been introduced to assess the global outcome after brain injuries. Therefore, we aimed to evaluate the prognostic factors associated with GOSE. Materials and Methods: This was a multicenter cross-sectional study conducted on 144 patients with TBI admitted at trauma emergency centers. The patients' information, including demographic characteristics, duration of hospital stay, mechanical ventilation and on-admission laboratory measurements, and on-admission vital signs, were evaluated. The patients' TBI-related symptoms and brain computed tomography (CT) scan findings were recorded. Results: GOSE assessments showed an increasing trend by the comparison of on-discharge (7.47 ± 1.30), within a month (7.51 ± 1.30) and within 3 months (7.58 ± 1.21) evaluations (P < 0.001). On-discharge GOSE was positively correlated with Glasgow Coma Scale (GCS)(r = 0.729, P < 0.001), motor GCS (r = 0.812, P < 0.001), Hb (r = 0.165, P = 0.048), and pH (r = 0.165, P = 0.048) and inversely with age (r = −0.261, P = 0.002), hospitalization period (r = −0.678, P < 0.001), pulse rate (r = −0.256, P = 0.002), white blood cell (WBC) (r = −0.222, P = 0.008), and triglyceride (r = −0.218, P = 0.009). In multiple linear regression analysis, the associations were significant only for GCS (B = 0.102, 95% confidence interval [CI]: 0–0.202; P = 0.05), hospitalization stay duration (B = −0.004, 95% CI: −0.005–−0.003, P = 0.001), and WBC (B = 0.00001, 95% CI: 0.00000014–0.000025; P = 0.024). Among imaging signs and trauma-related symptoms in univariate analysis, intracranial hemorrhage (ICH), interventricular hemorrhage (IVH) (P = 0.006), subarachnoid hemorrhage (SAH) (P = 0.06; marginally at P < 0.1), subdural hemorrhage (SDH) (P = 0.032), and epidural hemorrhage (EDH) (P = 0.037) was significantly associated with GOSE at discharge in multivariable analysis. Conclusion: According to the current study findings, GCS, hospitalization stay duration, WBC and among imaging signs and trauma-related symptoms ICH, IVH, SAH, SDH, and EDH are independent significant predictors of GOSE at discharge in TBI patients. |
| first_indexed | 2024-04-11T06:04:10Z |
| format | Article |
| id | doaj.art-727200056ad943d0a0fea0fd8524aae3 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-11T06:04:10Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-727200056ad943d0a0fea0fd8524aae32022-12-22T04:41:33ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362022-01-01271838310.4103/jrms.jrms_290_22Prognostic factors in traumatic brain injuries in emergency departmentMohammad Javad BehzadniaMousareza AnbarloueiSeyed Morteza HosseiniAmir Bahador BoroumandBackground: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young adults. The Extended Glasgow Outcome Score (GOSE) has been introduced to assess the global outcome after brain injuries. Therefore, we aimed to evaluate the prognostic factors associated with GOSE. Materials and Methods: This was a multicenter cross-sectional study conducted on 144 patients with TBI admitted at trauma emergency centers. The patients' information, including demographic characteristics, duration of hospital stay, mechanical ventilation and on-admission laboratory measurements, and on-admission vital signs, were evaluated. The patients' TBI-related symptoms and brain computed tomography (CT) scan findings were recorded. Results: GOSE assessments showed an increasing trend by the comparison of on-discharge (7.47 ± 1.30), within a month (7.51 ± 1.30) and within 3 months (7.58 ± 1.21) evaluations (P < 0.001). On-discharge GOSE was positively correlated with Glasgow Coma Scale (GCS)(r = 0.729, P < 0.001), motor GCS (r = 0.812, P < 0.001), Hb (r = 0.165, P = 0.048), and pH (r = 0.165, P = 0.048) and inversely with age (r = −0.261, P = 0.002), hospitalization period (r = −0.678, P < 0.001), pulse rate (r = −0.256, P = 0.002), white blood cell (WBC) (r = −0.222, P = 0.008), and triglyceride (r = −0.218, P = 0.009). In multiple linear regression analysis, the associations were significant only for GCS (B = 0.102, 95% confidence interval [CI]: 0–0.202; P = 0.05), hospitalization stay duration (B = −0.004, 95% CI: −0.005–−0.003, P = 0.001), and WBC (B = 0.00001, 95% CI: 0.00000014–0.000025; P = 0.024). Among imaging signs and trauma-related symptoms in univariate analysis, intracranial hemorrhage (ICH), interventricular hemorrhage (IVH) (P = 0.006), subarachnoid hemorrhage (SAH) (P = 0.06; marginally at P < 0.1), subdural hemorrhage (SDH) (P = 0.032), and epidural hemorrhage (EDH) (P = 0.037) was significantly associated with GOSE at discharge in multivariable analysis. Conclusion: According to the current study findings, GCS, hospitalization stay duration, WBC and among imaging signs and trauma-related symptoms ICH, IVH, SAH, SDH, and EDH are independent significant predictors of GOSE at discharge in TBI patients.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=83;epage=83;aulast=Behzadniacomputed tomographyglasgow coma scaleglasgow outcome scaletraumatic brain injuriesx-ray |
| spellingShingle | Mohammad Javad Behzadnia Mousareza Anbarlouei Seyed Morteza Hosseini Amir Bahador Boroumand Prognostic factors in traumatic brain injuries in emergency department Journal of Research in Medical Sciences computed tomography glasgow coma scale glasgow outcome scale traumatic brain injuries x-ray |
| title | Prognostic factors in traumatic brain injuries in emergency department |
| title_full | Prognostic factors in traumatic brain injuries in emergency department |
| title_fullStr | Prognostic factors in traumatic brain injuries in emergency department |
| title_full_unstemmed | Prognostic factors in traumatic brain injuries in emergency department |
| title_short | Prognostic factors in traumatic brain injuries in emergency department |
| title_sort | prognostic factors in traumatic brain injuries in emergency department |
| topic | computed tomography glasgow coma scale glasgow outcome scale traumatic brain injuries x-ray |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=83;epage=83;aulast=Behzadnia |
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