Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics
Cancer stem cells (CSC) have been identified in several types of solid tumors. In some cases, CSC may be the source of all the tumor cells, the cause of the tumor’s resistance to chemotherapeutic agents, and the source of metastatic cells. Thus, a combination therapy targeting non-CSC tumor cells as...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/23/13044 |
| _version_ | 1797507711716294656 |
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| author | Ari Meerson Soliman Khatib Jamal Mahajna |
| author_facet | Ari Meerson Soliman Khatib Jamal Mahajna |
| author_sort | Ari Meerson |
| collection | DOAJ |
| description | Cancer stem cells (CSC) have been identified in several types of solid tumors. In some cases, CSC may be the source of all the tumor cells, the cause of the tumor’s resistance to chemotherapeutic agents, and the source of metastatic cells. Thus, a combination therapy targeting non-CSC tumor cells as well as specifically targeting CSCs holds the potential to be highly effective. Natural products (NPs) have been a historically rich source of biologically active compounds and are known for their ability to influence multiple signaling pathways simultaneously with negligible side effects. In this review, we discuss the potential of NPs in targeting multiple signaling pathways in CSC and their potential to augment the efficacy of standard cancer therapy. Specifically, we focus on the anti-CSC activities of flavonoids, FDA-approved drugs originating from natural sources. Additionally, we emphasize the potential of NPs in targeting microRNA-mediated signaling, given the roles of microRNA in the maintenance of the CSC phenotype. |
| first_indexed | 2024-03-10T04:52:20Z |
| format | Article |
| id | doaj.art-727379184299481ebd2e92c4a2b011f7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:20Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-727379184299481ebd2e92c4a2b011f72023-11-23T02:32:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122231304410.3390/ijms222313044Natural Products Targeting Cancer Stem Cells for Augmenting Cancer TherapeuticsAri Meerson0Soliman Khatib1Jamal Mahajna2Department of Natural Products and Nutrition, MIGAL—Galilee Research Institute, Kiryat Shmona 11016, IsraelDepartment of Natural Products and Nutrition, MIGAL—Galilee Research Institute, Kiryat Shmona 11016, IsraelDepartment of Natural Products and Nutrition, MIGAL—Galilee Research Institute, Kiryat Shmona 11016, IsraelCancer stem cells (CSC) have been identified in several types of solid tumors. In some cases, CSC may be the source of all the tumor cells, the cause of the tumor’s resistance to chemotherapeutic agents, and the source of metastatic cells. Thus, a combination therapy targeting non-CSC tumor cells as well as specifically targeting CSCs holds the potential to be highly effective. Natural products (NPs) have been a historically rich source of biologically active compounds and are known for their ability to influence multiple signaling pathways simultaneously with negligible side effects. In this review, we discuss the potential of NPs in targeting multiple signaling pathways in CSC and their potential to augment the efficacy of standard cancer therapy. Specifically, we focus on the anti-CSC activities of flavonoids, FDA-approved drugs originating from natural sources. Additionally, we emphasize the potential of NPs in targeting microRNA-mediated signaling, given the roles of microRNA in the maintenance of the CSC phenotype.https://www.mdpi.com/1422-0067/22/23/13044natural productscancer stem cellscancer therapyflavonoids |
| spellingShingle | Ari Meerson Soliman Khatib Jamal Mahajna Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics International Journal of Molecular Sciences natural products cancer stem cells cancer therapy flavonoids |
| title | Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics |
| title_full | Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics |
| title_fullStr | Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics |
| title_full_unstemmed | Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics |
| title_short | Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics |
| title_sort | natural products targeting cancer stem cells for augmenting cancer therapeutics |
| topic | natural products cancer stem cells cancer therapy flavonoids |
| url | https://www.mdpi.com/1422-0067/22/23/13044 |
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