Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq

Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq

Leishmania are protozoan parasites transmitted by the bite of sand fly vectors producing a wide spectrum of diseases in their mammalian hosts. These diverse clinical outcomes are directly associated with parasite strain and species diversity. Although Leishmania reproduction is mainly clonal, a cryp...

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Bibliographic Details
Main Authors: Isabelle Louradour, Tiago Rodrigues Ferreira, Emma Duge, Nadira Karunaweera, Andrea Paun, David Sacks
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
Leishmania
mating
Hap2
meiosis
hybridization
scRNA-seq
Online Access:https://elifesciences.org/articles/73488

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