Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak.
From 2007 through 2010, the Netherlands experienced a large Q-fever epidemic, with 4,107 notifications. The most serious complication of Q-fever is chronic Q-fever.In 2014, we contacted all 2,161 adult inhabitants of the first village in the Netherlands affected by the Q-fever epidemic and offered t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4489093?pdf=render |
| _version_ | 1811343634655608832 |
|---|---|
| author | Gabriëlla Morroy Wim van der Hoek Jelle Albers Roel A Coutinho Chantal P Bleeker-Rovers Peter M Schneeberger |
| author_facet | Gabriëlla Morroy Wim van der Hoek Jelle Albers Roel A Coutinho Chantal P Bleeker-Rovers Peter M Schneeberger |
| author_sort | Gabriëlla Morroy |
| collection | DOAJ |
| description | From 2007 through 2010, the Netherlands experienced a large Q-fever epidemic, with 4,107 notifications. The most serious complication of Q-fever is chronic Q-fever.In 2014, we contacted all 2,161 adult inhabitants of the first village in the Netherlands affected by the Q-fever epidemic and offered to test for antibodies against Coxiella burnetii using immunofluorescence assay (IFA) to screen for chronic infections and assess whether large-scale population screening elsewhere is warranted.Of the 1,517 participants, 33.8% were IFA-positive. Six IFA-positive participants had an IgG phase I titer ≥1:512. Two of these six participants were previously diagnosed with chronic Q-fever. Chronic infection was diagnosed in one of the other four participants after clinical examination.Seven years after the initial outbreak, seroprevalence remains high, but the yield of screening the general population for chronic Q-fever is low. A policy of screening known high-risk groups for chronic Q-fever in outbreak areas directly following an outbreak might be more efficient than population screening. A cost-effectiveness analysis should also be performed before initiating a population screening program for chronic Q-fever. |
| first_indexed | 2024-04-13T19:33:19Z |
| format | Article |
| id | doaj.art-7279b3447b3147cc931883c2fd9da6f5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T19:33:19Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7279b3447b3147cc931883c2fd9da6f52022-12-22T02:33:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013177710.1371/journal.pone.0131777Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak.Gabriëlla MorroyWim van der HoekJelle AlbersRoel A CoutinhoChantal P Bleeker-RoversPeter M SchneebergerFrom 2007 through 2010, the Netherlands experienced a large Q-fever epidemic, with 4,107 notifications. The most serious complication of Q-fever is chronic Q-fever.In 2014, we contacted all 2,161 adult inhabitants of the first village in the Netherlands affected by the Q-fever epidemic and offered to test for antibodies against Coxiella burnetii using immunofluorescence assay (IFA) to screen for chronic infections and assess whether large-scale population screening elsewhere is warranted.Of the 1,517 participants, 33.8% were IFA-positive. Six IFA-positive participants had an IgG phase I titer ≥1:512. Two of these six participants were previously diagnosed with chronic Q-fever. Chronic infection was diagnosed in one of the other four participants after clinical examination.Seven years after the initial outbreak, seroprevalence remains high, but the yield of screening the general population for chronic Q-fever is low. A policy of screening known high-risk groups for chronic Q-fever in outbreak areas directly following an outbreak might be more efficient than population screening. A cost-effectiveness analysis should also be performed before initiating a population screening program for chronic Q-fever.http://europepmc.org/articles/PMC4489093?pdf=render |
| spellingShingle | Gabriëlla Morroy Wim van der Hoek Jelle Albers Roel A Coutinho Chantal P Bleeker-Rovers Peter M Schneeberger Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak. PLoS ONE |
| title | Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak. |
| title_full | Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak. |
| title_fullStr | Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak. |
| title_full_unstemmed | Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak. |
| title_short | Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak. |
| title_sort | population screening for chronic q fever seven years after a major outbreak |
| url | http://europepmc.org/articles/PMC4489093?pdf=render |
| work_keys_str_mv | AT gabriellamorroy populationscreeningforchronicqfeversevenyearsafteramajoroutbreak AT wimvanderhoek populationscreeningforchronicqfeversevenyearsafteramajoroutbreak AT jellealbers populationscreeningforchronicqfeversevenyearsafteramajoroutbreak AT roelacoutinho populationscreeningforchronicqfeversevenyearsafteramajoroutbreak AT chantalpbleekerrovers populationscreeningforchronicqfeversevenyearsafteramajoroutbreak AT petermschneeberger populationscreeningforchronicqfeversevenyearsafteramajoroutbreak |