NeuroCOVID: Insights into Neuroinvasion and Pathophysiology
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may lead to acute and chronic neurological symptoms (NeuroCOVID-19). SARS-CoV-2 may spread from the respiratory tract to the central nervous system as the central nervous system (CNS) of cert...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Clinical and Translational Neuroscience |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2514-183X/6/2/10 |
| _version_ | 1827661066569515008 |
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| author | Jakob Matschke Susanne Krasemann Hermann C. Altmeppen Mohsin Shafiq Markus Glatzel |
| author_facet | Jakob Matschke Susanne Krasemann Hermann C. Altmeppen Mohsin Shafiq Markus Glatzel |
| author_sort | Jakob Matschke |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may lead to acute and chronic neurological symptoms (NeuroCOVID-19). SARS-CoV-2 may spread from the respiratory tract to the central nervous system as the central nervous system (CNS) of certain patients dying from COVID-19 shows virus-related neuropathological changes. Moreover, a syndrome found in many patients having passed a SARS-CoV-2 infection, which is termed long COVID and characterized by lasting fatigue and other diverse clinical features, may well have some of its pathological correlates inside the CNS. Although knowledge on the routes of SARS-CoV-2 neuroinvasion and the pathophysiology of NeuroCOVID have increased, the molecular mechanisms are not yet fully understood. This includes the key question: to understand if observed CNS damage is a direct cause of viral damage or indirectly mediated by an overshooting neuroimmune response. |
| first_indexed | 2024-03-10T00:03:17Z |
| format | Article |
| id | doaj.art-7279ba9c4dba4ab59aff3752eb08dcfc |
| institution | Directory Open Access Journal |
| issn | 2514-183X |
| language | English |
| last_indexed | 2024-03-10T00:03:17Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinical and Translational Neuroscience |
| spelling | doaj.art-7279ba9c4dba4ab59aff3752eb08dcfc2023-11-23T16:13:30ZengMDPI AGClinical and Translational Neuroscience2514-183X2022-04-01621010.3390/ctn6020010NeuroCOVID: Insights into Neuroinvasion and PathophysiologyJakob Matschke0Susanne Krasemann1Hermann C. Altmeppen2Mohsin Shafiq3Markus Glatzel4Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may lead to acute and chronic neurological symptoms (NeuroCOVID-19). SARS-CoV-2 may spread from the respiratory tract to the central nervous system as the central nervous system (CNS) of certain patients dying from COVID-19 shows virus-related neuropathological changes. Moreover, a syndrome found in many patients having passed a SARS-CoV-2 infection, which is termed long COVID and characterized by lasting fatigue and other diverse clinical features, may well have some of its pathological correlates inside the CNS. Although knowledge on the routes of SARS-CoV-2 neuroinvasion and the pathophysiology of NeuroCOVID have increased, the molecular mechanisms are not yet fully understood. This includes the key question: to understand if observed CNS damage is a direct cause of viral damage or indirectly mediated by an overshooting neuroimmune response.https://www.mdpi.com/2514-183X/6/2/10SARS-CoV-2COVID-19neuroinvasionvagal nerveblood–brain barrierneurovascular unit |
| spellingShingle | Jakob Matschke Susanne Krasemann Hermann C. Altmeppen Mohsin Shafiq Markus Glatzel NeuroCOVID: Insights into Neuroinvasion and Pathophysiology Clinical and Translational Neuroscience SARS-CoV-2 COVID-19 neuroinvasion vagal nerve blood–brain barrier neurovascular unit |
| title | NeuroCOVID: Insights into Neuroinvasion and Pathophysiology |
| title_full | NeuroCOVID: Insights into Neuroinvasion and Pathophysiology |
| title_fullStr | NeuroCOVID: Insights into Neuroinvasion and Pathophysiology |
| title_full_unstemmed | NeuroCOVID: Insights into Neuroinvasion and Pathophysiology |
| title_short | NeuroCOVID: Insights into Neuroinvasion and Pathophysiology |
| title_sort | neurocovid insights into neuroinvasion and pathophysiology |
| topic | SARS-CoV-2 COVID-19 neuroinvasion vagal nerve blood–brain barrier neurovascular unit |
| url | https://www.mdpi.com/2514-183X/6/2/10 |
| work_keys_str_mv | AT jakobmatschke neurocovidinsightsintoneuroinvasionandpathophysiology AT susannekrasemann neurocovidinsightsintoneuroinvasionandpathophysiology AT hermanncaltmeppen neurocovidinsightsintoneuroinvasionandpathophysiology AT mohsinshafiq neurocovidinsightsintoneuroinvasionandpathophysiology AT markusglatzel neurocovidinsightsintoneuroinvasionandpathophysiology |