Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders
Abstract Nocturnal enuresis (NE) is a common problem among 10% school-aged children. The etiologies underlying childhood NE is complex and not fully understood nowadays. Nevertheless, increasing evidence suggests a potential link between neurobehavioral disorders and enuresis in children. In this st...
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Nature Portfolio
2021-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-96104-1 |
| _version_ | 1818993984422281216 |
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| author | Mei-Ching Yu Ta-Min Wang Yee-Hsuan Chiou Meng-Kung Yu Chiao-Fan Lin Chih-Yung Chiu |
| author_facet | Mei-Ching Yu Ta-Min Wang Yee-Hsuan Chiou Meng-Kung Yu Chiao-Fan Lin Chih-Yung Chiu |
| author_sort | Mei-Ching Yu |
| collection | DOAJ |
| description | Abstract Nocturnal enuresis (NE) is a common problem among 10% school-aged children. The etiologies underlying childhood NE is complex and not fully understood nowadays. Nevertheless, increasing evidence suggests a potential link between neurobehavioral disorders and enuresis in children. In this study, we aimed to explore novel metabolomic insights into the pathophysiology of NE and also, its association with pediatric psychiatric problems. Urine collected from 41 bedwetting children and 27 healthy control children was analyzed by using 1H-nuclear magnetic resonance spectroscopy from August 2017 to December 2018. At regular follow-up, there were 14 children with refractory NE having a diagnosis of attention deficient hyperactivity disorder (ADHD) or anxiety. Eventually, we identified eight significantly differential urinary metabolites and particularly increased urinary excretion of betaine, creatine and guanidinoacetate linked to glycine, serine and threonine metabolism were associated with a comorbidity of neurobehavioral disorders in refractory bedwetting children. Notably, based on physiological functions of betaine acting as a renal osmolyte and methyl group donor, we speculated its potential role in modulation of renal and/or central circadian clock systems, becoming a useful urinary metabolic marker in diagnosis of treatment-resistant NE in children affected by these two disorders. |
| first_indexed | 2024-12-20T20:50:44Z |
| format | Article |
| id | doaj.art-727b5826c3324bb3854eb0d231174e37 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T20:50:44Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-727b5826c3324bb3854eb0d231174e372022-12-21T19:26:56ZengNature PortfolioScientific Reports2045-23222021-08-011111910.1038/s41598-021-96104-1Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disordersMei-Ching Yu0Ta-Min Wang1Yee-Hsuan Chiou2Meng-Kung Yu3Chiao-Fan Lin4Chih-Yung Chiu5Division of Pediatric Nephrology, Department of Pediatrics, Lin-Kou Chang Gung Memorial Hospital and College of Medicine, Chang Gung UniversityDivision of Pediatric Urology, Department of Urology, Lin-Kou Chang Gung Memorial Hospital and College of Medicine, Chang Gung UniversityDepartment of Pediatrics, Kaohsiung Veterans General HospitalDepartment of Pediatrics, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDepartment of Child and Adolescent Psychiatry, Lin-Kou Chang Gung Memorial HospitalDivision of Pediatric Pulmonology, Department of Pediatrics, Clinical Metabolomics Core Laboratory, Lin-Kou Chang Gung Memorial Hospital and College of Medicine, Chang Gung UniversityAbstract Nocturnal enuresis (NE) is a common problem among 10% school-aged children. The etiologies underlying childhood NE is complex and not fully understood nowadays. Nevertheless, increasing evidence suggests a potential link between neurobehavioral disorders and enuresis in children. In this study, we aimed to explore novel metabolomic insights into the pathophysiology of NE and also, its association with pediatric psychiatric problems. Urine collected from 41 bedwetting children and 27 healthy control children was analyzed by using 1H-nuclear magnetic resonance spectroscopy from August 2017 to December 2018. At regular follow-up, there were 14 children with refractory NE having a diagnosis of attention deficient hyperactivity disorder (ADHD) or anxiety. Eventually, we identified eight significantly differential urinary metabolites and particularly increased urinary excretion of betaine, creatine and guanidinoacetate linked to glycine, serine and threonine metabolism were associated with a comorbidity of neurobehavioral disorders in refractory bedwetting children. Notably, based on physiological functions of betaine acting as a renal osmolyte and methyl group donor, we speculated its potential role in modulation of renal and/or central circadian clock systems, becoming a useful urinary metabolic marker in diagnosis of treatment-resistant NE in children affected by these two disorders.https://doi.org/10.1038/s41598-021-96104-1 |
| spellingShingle | Mei-Ching Yu Ta-Min Wang Yee-Hsuan Chiou Meng-Kung Yu Chiao-Fan Lin Chih-Yung Chiu Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders Scientific Reports |
| title | Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders |
| title_full | Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders |
| title_fullStr | Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders |
| title_full_unstemmed | Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders |
| title_short | Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders |
| title_sort | urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders |
| url | https://doi.org/10.1038/s41598-021-96104-1 |
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