Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia/Reperfusion Injury to the Cardiomyocytes

Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia/Reperfusion Injury to the Cardiomyocytes

Ischaemia, followed by reperfusion, causes the generation of reactive oxygen species, overproduction of peroxynitrite, activation of matrix metalloproteinases (MMPs), and subsequently the degradation of heart contractile proteins in the cardiomyocytes. Klotho is a membrane-bound or soluble protein t...

Full description

Bibliographic Details
Main Authors:	Agnieszka Olejnik, Anna Krzywonos-Zawadzka, Marta Banaszkiewicz, Iwona Bil-Lula
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	International Journal of Molecular Sciences
Subjects:	Klotho protein cardioprotection ischaemia/reperfusion injury matrix metalloproteinases heart conctractile proteins
Online Access:	https://www.mdpi.com/1422-0067/23/24/15450

Similar Items

Klotho as a Novel Cardioprotective Protein in Aged Heart
by: Ali Dehghani, et al.
Published: (2018-12-01)

KLOTHO PROTEIN AND ATHEROSCLEROSIS
by: O. V. Timoshchenko, et al.
Published: (2017-12-01)

Δ9-Tetrahydrocannabinol (Δ9-THC) Improves Ischemia/Reperfusion Heart Dysfunction and Might Serve as a Cardioprotective Agent in the Future Treatment
by: Marta Banaszkiewicz, et al.
Published: (2022-04-01)

Serum Klotho protein level in type 2 diabetic patients depending on the renal function
by: I. Topchii, et al.
Published: (2020-06-01)

Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein
by: Ahmad Almilaji, et al.
Published: (2014-12-01)

The Role of Soluble α-klotho Protein in Acromegaly
by: Oana PINZARIU, et al.
Published: (2023-03-01)

The Klotho protein in blood in men with ischemic heart disease and its association with a lipid profile
by: O. V. Timoshchenko, et al.
Published: (2020-03-01)

Research progress on the role of Klotho in heart failure
by: CHAI Yaru, DENG Yuting, DAI Hongyan, GUAN Jun
Published: (2023-06-01)

THE KLOTHO PROTEIN CONTENT AND LIPID BLOOD PROFILE BY AGE IN MEN 20-65 YEARS
by: O. V. Timoshchenko, et al.
Published: (2018-09-01)

The effect of Klotho protein complexed with nanomaterials on bone mesenchymal stem cell performance in the treatment of diabetic ischaemic ulcer
by: Rui Tang, et al.
Published: (2022-12-01)

Evaluation of the bone tissue metabolism in patients with generalized periodontitis of various degrees exposed to work-related harmful factors by the oral fluid Klotho protein content
by: I. V. Vozna, et al.
Published: (2021-04-01)

Klotho protein in men with type 2 diabetes mellitus blood and its association with cardiometabolic risk factors
by: O. V. Timoshchenko, et al.
Published: (2021-04-01)

The cardioprotective effect of S. africana caerulea/Blue Sage in ischaemia and reperfusion induced oxidative stress
by: Ruduwaan Salie, et al.
Published: (2023-09-01)

Relationship between Serum Soluble Klotho Protein and Coronary Artery Calcification and Prognosis in Patients on Maintenance Hemodialysis
by: Shubei ZHENG, et al.
Published: (2018-04-01)

The greater effect of high-intensity interval training versus moderate-intensity continuous training on cardioprotection against ischemia-reperfusion injury through Klotho levels and attenuate of myocardial TRPC6 expression
by: Maral Ramez, et al.
Published: (2019-05-01)

Correlation between Klotho changes and calcium-phosphate concentration in the serum at early stages of multiple sclerosis
by: Mehdi Amiri, et al.
Published: (2017-03-01)

Dynamic Changes and Associated Clinical Value of Serum Soluble α-Klotho Protein for Patients with Severe Craniocerebral Injury
by: Bin REN, Leifang YANG, Xinmin DING, Jifang LIANG
Published: (2022-07-01)

Klotho inhibits IGF1R/PI3K/AKT signalling pathway and protects the heart from oxidative stress during ischemia/reperfusion injury
by: Agnieszka Olejnik, et al.
Published: (2023-11-01)

Anti-Protease Activity Deficient Secretory Leukocyte Protease Inhibitor (SLPI) Exerts Cardioprotective Effect against Myocardial Ischaemia/Reperfusion
by: Podsawee Mongkolpathumrat, et al.
Published: (2022-04-01)

Klotho Ameliorates Chemically Induced Endoplasmic Reticulum (ER) Stress Signaling
by: Srijita Banerjee, et al.
Published: (2013-05-01)

High-protein and low-calorie diets improved the anti-aging Klotho protein in the rats’ brain: the toxic role of high-fat diet
by: Anahid Shafie, et al.
Published: (2020-10-01)

Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
by: Marlena Typiak, et al.
Published: (2021-01-01)

Soluble klotho as an effective biomarker to characterize inflammatory states
by: Shou-En Wu, et al.
Published: (2022-12-01)

Treatment of myocardial ischaemia-reperfusion injury in patients with ST-segment elevation myocardial infarction: promise, disappointment, and hope
by: Jingzhou He, et al.
Published: (2022-01-01)

Alterations in mitochondrial protein glycosylation in myocardial ischaemia reperfusion injury
by: Xinyu Feng, et al.
Published: (2023-09-01)

Association between serum Klotho concentration and hyperlipidemia in adults: a cross-sectional study from NHANES 2007–2016
by: Shaohua Yan, et al.
Published: (2023-11-01)

The impact of SGLT2 inhibitors on αKlotho in renal MDCK and HK-2 cells
by: Lisa Wolf, et al.
Published: (2023-03-01)

Tissue Expression of Atrial and Ventricular Myosin Light Chains in the Mechanism of Adaptation to Oxidative Stress
by: Marta Banaszkiewicz, et al.
Published: (2020-11-01)

Association between Soluble α-Klotho Protein and Metabolic Syndrome in the Adult Population
by: Yung-Wen Cheng, et al.
Published: (2022-01-01)

Association between Klotho protein and melanoma and nonmelanoma skin cancer in the US adult population: A cross-sectional study
by: Nargiza Sadr, BSN, MS2, et al.
Published: (2023-12-01)

Serum Klotho as a marker for early diagnosis of acute kidney injury after cardiac surgery
by: Jerin Aleš, et al.
Published: (2020-01-01)

Discovery of Klotho peptide antagonists against Wnt3 and Wnt3a target proteins using combination of protein engineering, protein–protein docking, peptide docking and molecular dynamics simulations
by: Shaher Bano Mirza, et al.
Published: (2017-01-01)

The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements
by: Jean-Sébastien Paquette, et al.
Published: (2023-11-01)

References Values of Soluble α-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18–85 Years
by: Andrea Espuch-Oliver, et al.
Published: (2022-04-01)

Klotho and the Treatment of Human Malignancies
by: Aishani Sachdeva, et al.
Published: (2020-06-01)

The role of klotho in systemic sclerosis
by: R. Talotta, et al.
Published: (2017-12-01)

The effect of Nitroprusside on the renal ischaemia-reperfusion injury
by: Kadkhodaee M, et al.
Published: (2002-03-01)

The effect of Nitroprusside on the renal ischaemia-reperfusion injury
by: Kadkhodaee M, et al.
Published: (2002-05-01)

Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice
by: Kitti Szőke, et al.
Published: (2023-06-01)

Serum soluble alpha-klotho klotho and cognitive functioning in older adults aged 60 and 79: an analysis of cross-sectional data of the National Health and Nutrition Examination Survey 2011 to 2014
by: Song Ge, et al.
Published: (2024-03-01)